{"created":"2022-02-14T04:07:30.141610+00:00","id":2002095,"links":{},"metadata":{"_buckets":{"deposit":"76537a4d-c4c3-4506-bc06-666a7380108e"},"_deposit":{"created_by":17,"id":"2002095","owner":"17","owners":[17],"owners_ext":{"displayname":"図書情報係","username":"repository"},"pid":{"revision_id":0,"type":"depid","value":"2002095"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02002095","sets":["643:666:667"]},"author_link":[],"control_number":"2002095","item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1629683748249":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-10-01","subitem_date_issued_type":"Available"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"bqab140","bibliographicVolumeNumber":"162","bibliographic_titles":[{"bibliographic_title":"Endocrinology","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Energetic status often affects reproductive function, glucose homeostasis, and feeding in mammals. Malnutrition suppresses pulsatile release of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) and increases gluconeogenesis and feeding. The present study aims to examine whether β-endorphin-μ-opioid receptor (MOR) signaling mediates the suppression of pulsatile GnRH/LH release and an increase in gluconeogenesis/feeding induced by malnutrition. Ovariectomized female rats treated with a negative feedback level of estradiol-17β (OVX + low E2) receiving 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, intravenously (iv) were used as a malnutrition model. An administration of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), a selective MOR antagonist, into the third ventricle blocked the suppression of the LH pulse and increase in gluconeogenesis/feeding induced by iv 2DG administration. Histological analysis revealed that arcuate Kiss1 (kisspeptin gene)-expressing cells and preoptic Gnrh1 (GnRH gene)-expressing cells co-expressed little Oprm1 (MOR gene), while around 10% of arcuate Slc17a6 (glutamatergic marker gene)-expressing cells co-expressed Oprm1. Further, the CTOP treatment decreased the number of fos-positive cells in the paraventricular nucleus (PVN) in OVX + low E2 rats treated with iv 2DG but failed to affect the number of arcuate fos-expressing Slc17a6-positive cells. Taken together, these results suggest that the central β-endorphin-MOR signaling mediates the suppression of pulsatile LH release and that the β-endorphin may indirectly suppress the arcuate kisspeptin neurons, a master regulator for GnRH/LH pulses during malnutrition. Furthermore, the current study suggests that central β-endorphin-MOR signaling is also involved in gluconeogenesis and an increase in food intake by directly or indirectly acting on the PVN neurons during malnutrition in female rats.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1210/endocr/bqab140","subitem_relation_type_select":"DOI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is a pre-copyedited, author-produced version of an article accepted for publication in [Endocrinology] following peer review. The version of record [Hitomi Tsuchida, Narumi Kawai, Koki Yamada, Marina Takizawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats, Endocrinology, Volume 162, Issue 10, October 2021, bqab140, https://doi.org/10.1210/endocr/bqab140] is available online at: https://doi.org/10.1210/endocr/bqab140.","subitem_rights_language":"en"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0013-7227","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuchida, Hitomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawai, Narumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamada, Koki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takizawa, Marina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inoue, Naoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uenoyama, Yoshihisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsukamura, Hiroko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-01"}],"displaytype":"detail","filename":"Tsuchida_et_al_2021_Endocrinology.pdf","filesize":[{"value":"20.9 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2002095/files/Tsuchida_et_al_2021_Endocrinology.pdf"},"version_id":"63ef69fd-3d8e-432e-b50e-a4fac8eab844"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"malnutrition","subitem_subject_scheme":"Other"},{"subitem_subject":"kisspeptin neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"GnRH neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"glutamatergic neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"proopiomelanocortin neuron","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["667"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-02-14"},"publish_date":"2022-02-14","publish_status":"0","recid":"2002095","relation_version_is_last":true,"title":["Central µ-Opioid Receptor Antagonism Blocks Glucoprivic LH Pulse Suppression and Gluconeogenesis/Feeding in Female Rats"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-01-16T05:13:03.014630+00:00"}