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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 84(1)

A long-term survivor of advanced retroperitoneal dedifferentiated liposarcoma: a successful multimodal approach with extended resection and chemotherapy

https://doi.org/10.18999/nagjms.84.1.200
https://doi.org/10.18999/nagjms.84.1.200
2fff77a8-7f63-4eda-b929-2528d250ab2e
名前 / ファイル ライセンス アクション
21_Nakahashi.pdf 21_Nakahashi.pdf (44 MB)
Item type itemtype_ver1(1)
公開日 2022-02-28
タイトル
タイトル A long-term survivor of advanced retroperitoneal dedifferentiated liposarcoma: a successful multimodal approach with extended resection and chemotherapy
言語 en
著者 Nakahashi, Koichi

× Nakahashi, Koichi

en Nakahashi, Koichi

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Yokoyama, Yukihiro

× Yokoyama, Yukihiro

en Yokoyama, Yukihiro

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Fukaya, Masahide

× Fukaya, Masahide

en Fukaya, Masahide

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Igami, Tsuyoshi

× Igami, Tsuyoshi

en Igami, Tsuyoshi

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Mizuno, Takashi

× Mizuno, Takashi

en Mizuno, Takashi

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Yamaguchi, Junpei

× Yamaguchi, Junpei

en Yamaguchi, Junpei

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Onoe, Shunsuke

× Onoe, Shunsuke

en Onoe, Shunsuke

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Watanabe, Nobuyuki

× Watanabe, Nobuyuki

en Watanabe, Nobuyuki

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Ebata, Tomoki

× Ebata, Tomoki

en Ebata, Tomoki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
言語 en
主題Scheme Other
主題 retroperitoneal liposarcoma
キーワード
言語 en
主題Scheme Other
主題 dedifferentiated
キーワード
言語 en
主題Scheme Other
主題 chemotherapy
キーワード
言語 en
主題Scheme Other
主題 extended surgery
内容記述
内容記述 Surgical resection is the mainstay of treatment for retroperitoneal liposarcoma (RPLS). Herein, we describe a case of dedifferentiated RPLS successfully treated with an extended surgical approach with adjuvant chemotherapy. A 61-year-old male was referred to our hospital with a chief complaint of chest tightness. Abdominal computed tomography revealed a large retroperitoneal tumor, 11 cm in diameter, extensively invading the surrounding organs: the celiac axis, the splenic artery, the pancreatic body and tail, the lesser curvature of the stomach and the left adrenal gland. Endoscopic ultrasound-guided fine-needle aspiration biopsy confirmed dedifferentiated liposarcoma, suggesting aggressive tumor biology. We performed total gastrectomy combined with distal pancreatectomy with celiac axis and left adrenal gland resection with a curative intent. The postoperative course was almost uneventful. As the pathological findings indicated a positive margin with a well-differentiated liposarcoma component, we added adjuvant chemotherapy with four cycles of doxorubicin and ifosfamide (AI). Five years after primary surgery, regular follow-up CT demonstrated a pulmonary hilar lymph node enlargement and a tumor at paraesophageal locations. After downsizing chemotherapy with eribulin followed by pazopanib, he underwent partial esophagectomy with dissection of the paraesophageal tumor. The pathological findings indicated recurrence of dedifferentiated liposarcoma with a tumor-free surgical margin. He is currently alive without any evidence of recurrence almost 7 years after the first surgery and 15 months after the second surgery. The long-term survival gained in this patient indicates that extended resections and adjuvant chemotherapy could prolong survival in patients even with RPLS with dedifferentiated tumor histology.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.84.1.200
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/841.html
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 84, 号 1, p. 200-207, 発行日 2022-02
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