@article{oai:nagoya.repo.nii.ac.jp:02002214,
 author = {Tanaka, Yasuhiro and Tsuboi, Takashi and Watanabe, Hirohisa and Torii, Jun and Nakatsubo, Daisuke and Maesawa, Satoshi and Sato, Maki and Hiraga, Keita and Satake, Yuki and Yokoi, Katsunori and Hattori, Makoto and Kawabata, Kazuya and Hara, Kazuhiro and Yamamoto, Masahiko and Sobue, Gen and Katsuno, Masahisa},
 journal = {Parkinsonism & Related Disorders},
 month = {Dec},
 note = {Introduction: The impact of deep brain stimulation (DBS) on speech rhythm and its mechanism remains unclear. We investigated speech rhythm characteristics of patients with Parkinson's disease (PD) treated with subthalamic nucleus (STN) DBS to understand the underlying pathophysiology better. Methods: We enrolled a total of 105 participants and evaluated speech rhythm performances among patients with PD who had undergone STN-DBS (the PD-DBS group), patients with PD treated only with medication (the PD-Med group), patients with cerebellar ataxia (the CA group), and healthy controls (the HC group). Each participant was asked to repeat the syllable/pa/at a comfortable self-chosen steady pace. A widely-used software (the Motor Speech Profile) program performed an acoustic analysis. Results: Compared to the PD-Med and HC groups, speech rate instability (DDKjit) was significantly higher in the PD-DBS and CA groups (p < 0.01). However, after DBS was turned off, the DDKjit of the PD-DBS group improved to a level comparable to that of the PD-Med and HC groups. In contrast to the significantly higher variability of speech volume (DDKcvi) in the CA group, the PD-DBS group showed similar DDKcvi to the PD-Med and HC groups. Conclusions: STN-DBS affects the speech rate stability of patients with PD. Speech rhythm disorders caused by STN-DBS were phenotypically similar to that in CA in terms of interval variability but different regarding amplitude variability. Further studies are warranted to elucidate the underlying pathophysiology of speech rhythm disorders in PD patients treated with DBS.},
 pages = {8--11},
 title = {Instability of speech in Parkinson disease patients with subthalamic nucleus deep brain stimulation},
 volume = {93},
 year = {2021}
}