{"_buckets": {"deposit": "390d6acb-1c11-4872-a903-f2290b416170"}, "_deposit": {"created_by": 17, "id": "2002691", "owner": "17", "owners": [17], "owners_ext": {"displayname": "repository", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2002691"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02002691"}, "author_link": [], "item_1615768549627": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "\u65e5\u4ed8", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2023-01-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "105981", "bibliographicVolumeNumber": "175", "bibliographic_titles": [{"bibliographic_title": "Pharmacological Research", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "Inchinkoto (ICKT) is a popular choleretic and hepatoprotective herbal medicine that is widely used in Japan. Geniposide, a major ingredient of ICKT, is metabolized to genipin by gut microbiota, which exerts a choleretic effect. This study investigates the relationship between stool genipin-producing activity and diversity of the clinical effect of ICKT in patients with malignant obstructive jaundice. Fifty-two patients with malignant obstructive jaundice who underwent external biliary drainage were included. ICKT was administered as three packets per day (7.5 g/day) for three days and 2.5 g on the morning of the fourth day. Stool samples were collected before ICKT administration and bile flow was monitored on a daily basis. The microbiome, genipin-producing activity, and organic acids in stools were analyzed. The Shannon-Wiener (SW) index was calculated to evaluate gut microbiome diversity. The stool genipin-producing activity showed a significant positive correlation with the SW index. Stool genipin-producing activity positively correlated with the order Clostridia (obligate anaerobes), but negatively correlated with the order Lactobacillales (facultative anaerobes). Moreover, stool genipin-producing activity was positively correlated to the concentration valeric acid, but negatively correlated to the concentration of lactic acid and succinic acid. The change of bile flow at 2 and 3 days after ICKT administration showed significant positive correlation with genipin-producing activity (correlation coefficient, 0.40 and 0.29, respectively, P \u003c 0.05). An analysis of stool profile, including stool genipin-producing activity, may predict the efficacy of ICKT. Modification of the microbiome may be a target to enhance the therapeutic effect of ICKT.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "\u95a2\u9023\u60c5\u5831", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.phrs.2021.105981", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "\u53ce\u9332\u7269\u8b58\u5225\u5b50", "attribute_value_mlt": [{"subitem_source_identifier": "1043-6618", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "embargoed access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_f1cf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamashita, Hiromasa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nishiyama, Mitsue", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohbuchi, Katsuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kanno, Hitomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tsuchiya, Kazuaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamaguchi, Junpei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mizuno, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ebata, Tomoki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nagino, Masato", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yokoyama, Yukihiro", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-01-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2022/12/31.", "file_order": 0, "filename": "ICKT_Pharm_Res_2022.pdf", "filesize": [{"value": "891 KB"}], "format": "application/pdf", "future_date_message": "Download is available from 2022/12/31.", "is_thumbnail": false, "mimetype": "application/pdf", "size": 891000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2002691/files/ICKT_Pharm_Res_2022.pdf"}, "version_id": "85ed416f-ebd7-4dc0-89eb-78d2fae9d1c3"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Obstructive jaundice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kampo", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inchinkoto", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genipin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Microbiome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bio-conversion", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/0002002691", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-05-10"}, "publish_date": "2022-05-10", "publish_status": "0", "recid": "2002691", "relation": {}, "relation_version_is_last": true, "title": ["Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics"], "weko_shared_id": -1}