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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics

http://hdl.handle.net/2237/0002002691
http://hdl.handle.net/2237/0002002691
144c0950-1913-482e-80bf-d994f47f0667
名前 / ファイル ライセンス アクション
ICKT_Pharm_Res_2022.pdf ICKT_Pharm_Res_2022.pdf (891 KB)
Item type itemtype_ver1(1)
公開日 2022-05-10
タイトル
タイトル Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics
言語 en
著者 Yamashita, Hiromasa

× Yamashita, Hiromasa

en Yamashita, Hiromasa

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Nishiyama, Mitsue

× Nishiyama, Mitsue

en Nishiyama, Mitsue

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Ohbuchi, Katsuya

× Ohbuchi, Katsuya

en Ohbuchi, Katsuya

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Kanno, Hitomi

× Kanno, Hitomi

en Kanno, Hitomi

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Tsuchiya, Kazuaki

× Tsuchiya, Kazuaki

en Tsuchiya, Kazuaki

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Yamaguchi, Junpei

× Yamaguchi, Junpei

en Yamaguchi, Junpei

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Mizuno, Takashi

× Mizuno, Takashi

en Mizuno, Takashi

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Ebata, Tomoki

× Ebata, Tomoki

en Ebata, Tomoki

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Nagino, Masato

× Nagino, Masato

en Nagino, Masato

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Yokoyama, Yukihiro

× Yokoyama, Yukihiro

en Yokoyama, Yukihiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Obstructive jaundice
キーワード
主題Scheme Other
主題 Kampo
キーワード
主題Scheme Other
主題 Inchinkoto
キーワード
主題Scheme Other
主題 Genipin
キーワード
主題Scheme Other
主題 Microbiome
キーワード
主題Scheme Other
主題 Bio-conversion
内容記述
内容記述 Inchinkoto (ICKT) is a popular choleretic and hepatoprotective herbal medicine that is widely used in Japan. Geniposide, a major ingredient of ICKT, is metabolized to genipin by gut microbiota, which exerts a choleretic effect. This study investigates the relationship between stool genipin-producing activity and diversity of the clinical effect of ICKT in patients with malignant obstructive jaundice. Fifty-two patients with malignant obstructive jaundice who underwent external biliary drainage were included. ICKT was administered as three packets per day (7.5 g/day) for three days and 2.5 g on the morning of the fourth day. Stool samples were collected before ICKT administration and bile flow was monitored on a daily basis. The microbiome, genipin-producing activity, and organic acids in stools were analyzed. The Shannon-Wiener (SW) index was calculated to evaluate gut microbiome diversity. The stool genipin-producing activity showed a significant positive correlation with the SW index. Stool genipin-producing activity positively correlated with the order Clostridia (obligate anaerobes), but negatively correlated with the order Lactobacillales (facultative anaerobes). Moreover, stool genipin-producing activity was positively correlated to the concentration valeric acid, but negatively correlated to the concentration of lactic acid and succinic acid. The change of bile flow at 2 and 3 days after ICKT administration showed significant positive correlation with genipin-producing activity (correlation coefficient, 0.40 and 0.29, respectively, P < 0.05). An analysis of stool profile, including stool genipin-producing activity, may predict the efficacy of ICKT. Modification of the microbiome may be a target to enhance the therapeutic effect of ICKT.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.phrs.2021.105981
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1043-6618
書誌情報 en : Pharmacological Research

巻 175, p. 105981, 発行日 2022-01
ファイル公開日
日付 2023-01-01
日付タイプ Available
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