Item type |
itemtype_ver1(1) |
公開日 |
2022-05-10 |
タイトル |
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タイトル |
Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics |
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言語 |
en |
著者 |
Yamashita, Hiromasa
Nishiyama, Mitsue
Ohbuchi, Katsuya
Kanno, Hitomi
Tsuchiya, Kazuaki
Yamaguchi, Junpei
Mizuno, Takashi
Ebata, Tomoki
Nagino, Masato
Yokoyama, Yukihiro
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利 |
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言語 |
en |
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権利情報 |
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
キーワード |
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主題Scheme |
Other |
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主題 |
Obstructive jaundice |
キーワード |
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主題Scheme |
Other |
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主題 |
Kampo |
キーワード |
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主題Scheme |
Other |
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主題 |
Inchinkoto |
キーワード |
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主題Scheme |
Other |
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主題 |
Genipin |
キーワード |
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主題Scheme |
Other |
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主題 |
Microbiome |
キーワード |
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主題Scheme |
Other |
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主題 |
Bio-conversion |
内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Inchinkoto (ICKT) is a popular choleretic and hepatoprotective herbal medicine that is widely used in Japan. Geniposide, a major ingredient of ICKT, is metabolized to genipin by gut microbiota, which exerts a choleretic effect. This study investigates the relationship between stool genipin-producing activity and diversity of the clinical effect of ICKT in patients with malignant obstructive jaundice. Fifty-two patients with malignant obstructive jaundice who underwent external biliary drainage were included. ICKT was administered as three packets per day (7.5 g/day) for three days and 2.5 g on the morning of the fourth day. Stool samples were collected before ICKT administration and bile flow was monitored on a daily basis. The microbiome, genipin-producing activity, and organic acids in stools were analyzed. The Shannon-Wiener (SW) index was calculated to evaluate gut microbiome diversity. The stool genipin-producing activity showed a significant positive correlation with the SW index. Stool genipin-producing activity positively correlated with the order Clostridia (obligate anaerobes), but negatively correlated with the order Lactobacillales (facultative anaerobes). Moreover, stool genipin-producing activity was positively correlated to the concentration valeric acid, but negatively correlated to the concentration of lactic acid and succinic acid. The change of bile flow at 2 and 3 days after ICKT administration showed significant positive correlation with genipin-producing activity (correlation coefficient, 0.40 and 0.29, respectively, P < 0.05). An analysis of stool profile, including stool genipin-producing activity, may predict the efficacy of ICKT. Modification of the microbiome may be a target to enhance the therapeutic effect of ICKT. |
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言語 |
en |
出版者 |
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出版者 |
Elsevier |
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言語 |
en |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.phrs.2021.105981 |
収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1043-6618 |
書誌情報 |
en : Pharmacological Research
巻 175,
p. 105981,
発行日 2022-01
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ファイル公開日 |
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日付 |
2023-01-01 |
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日付タイプ |
Available |