{"created":"2022-05-10T01:09:54.976505+00:00","id":2002691,"links":{},"metadata":{"_buckets":{"deposit":"390d6acb-1c11-4872-a903-f2290b416170"},"_deposit":{"created_by":17,"id":"2002691","owner":"17","owners":[17],"owners_ext":{"displayname":"repository","username":"repository"},"pid":{"revision_id":0,"type":"depid","value":"2002691"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02002691"},"author_link":[],"item_1615768549627":{"attribute_name":"\u51fa\u7248\u30bf\u30a4\u30d7","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1629683748249":{"attribute_name":"\u65e5\u4ed8","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-01-01","subitem_date_issued_type":"Available"}]},"item_9_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"105981","bibliographicVolumeNumber":"175","bibliographic_titles":[{"bibliographic_title":"Pharmacological Research","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"\u5185\u5bb9\u8a18\u8ff0","attribute_value_mlt":[{"subitem_description":"Inchinkoto (ICKT) is a popular choleretic and hepatoprotective herbal medicine that is widely used in Japan. Geniposide, a major ingredient of ICKT, is metabolized to genipin by gut microbiota, which exerts a choleretic effect. This study investigates the relationship between stool genipin-producing activity and diversity of the clinical effect of ICKT in patients with malignant obstructive jaundice. Fifty-two patients with malignant obstructive jaundice who underwent external biliary drainage were included. ICKT was administered as three packets per day (7.5 g/day) for three days and 2.5 g on the morning of the fourth day. Stool samples were collected before ICKT administration and bile flow was monitored on a daily basis. The microbiome, genipin-producing activity, and organic acids in stools were analyzed. The Shannon-Wiener (SW) index was calculated to evaluate gut microbiome diversity. The stool genipin-producing activity showed a significant positive correlation with the SW index. Stool genipin-producing activity positively correlated with the order Clostridia (obligate anaerobes), but negatively correlated with the order Lactobacillales (facultative anaerobes). Moreover, stool genipin-producing activity was positively correlated to the concentration valeric acid, but negatively correlated to the concentration of lactic acid and succinic acid. The change of bile flow at 2 and 3 days after ICKT administration showed significant positive correlation with genipin-producing activity (correlation coefficient, 0.40 and 0.29, respectively, P < 0.05). An analysis of stool profile, including stool genipin-producing activity, may predict the efficacy of ICKT. Modification of the microbiome may be a target to enhance the therapeutic effect of ICKT.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"\u95a2\u9023\u60c5\u5831","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.phrs.2021.105981","subitem_relation_type_select":"DOI"}}]},"item_9_rights_12":{"attribute_name":"\u6a29\u5229","attribute_value_mlt":[{"subitem_rights":"\u00a9 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_9_source_id_7":{"attribute_name":"\u53ce\u9332\u7269\u8b58\u5225\u5b50","attribute_value_mlt":[{"subitem_source_identifier":"1043-6618","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"\u30a2\u30af\u30bb\u30b9\u6a29","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamashita, Hiromasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishiyama, Mitsue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohbuchi, Katsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanno, Hitomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsuchiya, Kazuaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Junpei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizuno, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ebata, Tomoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagino, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yokoyama, Yukihiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-01"}],"displaytype":"detail","filename":"ICKT_Pharm_Res_2022.pdf","filesize":[{"value":"891 KB"}],"format":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2002691/files/ICKT_Pharm_Res_2022.pdf"},"version_id":"85ed416f-ebd7-4dc0-89eb-78d2fae9d1c3"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Obstructive jaundice","subitem_subject_scheme":"Other"},{"subitem_subject":"Kampo","subitem_subject_scheme":"Other"},{"subitem_subject":"Inchinkoto","subitem_subject_scheme":"Other"},{"subitem_subject":"Genipin","subitem_subject_scheme":"Other"},{"subitem_subject":"Microbiome","subitem_subject_scheme":"Other"},{"subitem_subject":"Bio-conversion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["499/500/501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-10"},"publish_date":"2022-05-10","publish_status":"0","recid":"2002691","relation_version_is_last":true,"title":["Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2022-05-10T01:19:27.297425+00:00"}