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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

A Heme-Acquisition Protein Reconstructed with a Cobalt 5-Oxaporphyrinium Cation and Its Growth-Inhibition Activity Toward Multidrug-Resistant Pseudomonas aeruginosa

http://hdl.handle.net/2237/0002002706
http://hdl.handle.net/2237/0002002706
0d492fad-3da5-4eba-abd4-81ac2293a2e5
名前 / ファイル ライセンス アクション
manuscript.pdf manuscript.pdf (1.2 MB)
 Download is available from 2023/2/6.
Item type itemtype_ver1(1)
公開日 2022-05-11
タイトル
タイトル A Heme-Acquisition Protein Reconstructed with a Cobalt 5-Oxaporphyrinium Cation and Its Growth-Inhibition Activity Toward Multidrug-Resistant Pseudomonas aeruginosa
言語 en
著者 Takiguchi, Asahi

× Takiguchi, Asahi

en Takiguchi, Asahi

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Sakakibara, Erika

× Sakakibara, Erika

en Sakakibara, Erika

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Sugimoto, Hiroshi

× Sugimoto, Hiroshi

en Sugimoto, Hiroshi

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Shoji, Osami

× Shoji, Osami

en Shoji, Osami

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Shinokubo, Hiroshi

× Shinokubo, Hiroshi

en Shinokubo, Hiroshi

Search repository
アクセス権
アクセス権 embargoed access
アクセス権URI http://purl.org/coar/access_right/c_f1cf
権利
言語 en
権利情報 "This is the peer reviewed version of the following article: [A. Takiguchi, E. Sakakibara, H. Sugimoto, O. Shoji, H. Shinokubo, Angew. Chem. Int. Ed. 2022, 61, e202112456.], which has been published in final form at [https://doi.org/10.1002/anie.202112456]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."
内容記述
内容記述 Using artificial hemes for the reconstruction of natural heme proteins represents a fascinating approach to enhance the bioactivity of the latter. We report the synthesis of various metal 5-oxaporphyrinium cations as cofactors, and a cobalt 5-oxaporphyrinium cation was successfully incorporated into the heme-acquisition protein (HasA) secreted by Pseudomonas aeruginosa. We hypothesize that the oxaporphyrinium cation strongly binds to the HasA-specific outer membrane receptor (HasR) due to its cationic charge, which prevents the subsequent acquisition of heme. In fact, the reconstructed HasA inhibited the growth of Pseudomonas aeruginosa and even of multidrug-resistant P. aeruginosa.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/anie.202112456
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1433-7851
書誌情報 en : Angewandte Chemie International Edition

巻 61, 号 7, p. e202112456, 発行日 2022-02-07
ファイル公開日
日付 2023-02-07
日付タイプ Available
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