{"created":"2022-05-27T00:56:09.295726+00:00","id":2002874,"links":{},"metadata":{"_buckets":{"deposit":"ce0aa3d2-e63e-445a-ae7d-e9ba0dc5708f"},"_deposit":{"created_by":17,"id":"2002874","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2002874"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02002874","sets":["499:508:509:1653611787117"]},"author_link":[],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1615768833594":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K16318","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K16318/"},"subitem_award_titles":[{"subitem_award_title":"Trib1のエンハンサーリプログラミングによるAML悪性化機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"19K24694","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K24694/"},"subitem_award_titles":[{"subitem_award_title":"ゲノム相分離生物学の創出とがん研究への応用","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"229","bibliographicPageStart":"216","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Abnormalities in the regulation of gene expression are associated with various pathological conditions. Among the distal regulatory elements in the genome, the activation of target genes by enhancers plays a central role in the formation of cell type–specific gene expression patterns. Super-enhancers are a subclass of enhancers that frequently contain multiple enhancer-like elements and are characterized by dense binding of master transcription factors and Mediator complexes and high signals of active histone marks. Super-enhancers have been studied in detail as important regulatory regions that control cell identity and contribute to the pathogenesis of diverse diseases. In cancer, super-enhancers have multifaceted roles by activating various oncogenes and other cancer-related genes and shaping characteristic gene expression patterns in cancer cells. Alterations in super-enhancer activities in cancer involve multiple mechanisms, including the dysregulation of transcription factors and the super-enhancer–associated genomic abnormalities. The study of super-enhancers could contribute to the identification of effective biomarkers and the development of cancer therapeutics targeting transcriptional addiction. In this review, we summarize the roles of super-enhancers in cancer biology, with a particular focus on hematopoietic malignancies, in which multiple super-enhancer alteration mechanisms have been reported.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.84.2.216","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/842.html","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshino, Seiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Hiroshi I.","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"02_Yoshino.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2002874/files/02_Yoshino.pdf"},"version_id":"0c5f871e-dd57-4fea-8158-98656bff55a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"super-enhancer","subitem_subject_scheme":"Other"},{"subitem_subject":"oncogene","subitem_subject_scheme":"Other"},{"subitem_subject":"transcription factor","subitem_subject_scheme":"Other"},{"subitem_subject":"genome","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer therapy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The molecular understanding of super-enhancer dysregulation in cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The molecular understanding of super-enhancer dysregulation in cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["1653611787117"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-27"},"publish_date":"2022-05-27","publish_status":"0","recid":"2002874","relation_version_is_last":true,"title":["The molecular understanding of super-enhancer dysregulation in cancer"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T01:57:52.160192+00:00"}