@article{oai:nagoya.repo.nii.ac.jp:02002883,
 author = {Suzuki, Gen and Yamazaki, Hideya and Aibe, Norihiro and Masui, Koji and Shimizu, Daisuke and Kimoto, Takuya and Nagasawa, Shinsuke and Takenaka, Tadashi and Masai, Norihisa and Watanabe, Sho and Seri, Sho and Tamaki, Nagara and Takayama, Koichi and Yamada, Kei},
 issue = {2},
 journal = {Nagoya Journal of Medical Science},
 month = {May},
 note = {Elective nodal irradiation (ENI) and involved field radiotherapy (IFRT) are definitive radiotherapeutic approaches used to treat patients with limited-disease small cell lung cancer (LD-SCLC). However, no solid consensus exists on their optimal target volume. The current study aimed to assess the clinical outcomes of patients with LD-SCLC who received definitive ENI or IFRT. A retrospective single-institution study of patients who received definitive radiotherapy between 2008 and 2020 was performed. All patients underwent whole-body positron emission tomography/computed tomography before three-dimensional conformal radiotherapy. Among the 37 patients analyzed, 22 and 15 received ENI and IFRT, respectively. The thoracic radiotherapy dose was mostly either 60 Gy in 30 fractions delivered in 2-Gy fractions once daily or 45 Gy in 30 fractions delivered in 1.5-Gy fractions twice daily. The median follow-up period was 21.4 months. A total of 12 patients (32%) experienced locoregional relapse: 10 within and 2 outside the irradiation fields. One patient in the IFRT group experienced isolated nodal failure. Differences in locoregional relapse-free, progression-free, and overall survival rates between ENI and IFRT were not significant. Overall, IFRT did not promote a significant increase in locoregional recurrence compared to ENI. Our findings suggested the utility of IFRT in standard clinical practice and support its use for patients with LD-SCLC.},
 pages = {327--338},
 title = {Elective nodal irradiation versus involved field radiotherapy for limited disease small cell lung cancer: a single-institution experience},
 volume = {84},
 year = {2022}
}