@article{oai:nagoya.repo.nii.ac.jp:02002887,
 author = {Elshair, Moaz and Ugai, Tomotaka and Oze, Isao and Kasugai, Yumiko and Koyanagi, Yuriko N. and Hara, Kazuo and Ito, Hidemi and Matsuo, Keitaro},
 issue = {2},
 journal = {Nagoya Journal of Medical Science},
 month = {May},
 note = {Helicobacter pylori infection is a significant risk factor for gastric cancer. The infection is acquired mainly in early childhood and is influenced by environmental factors, including socioeconomic status and sibling number. However, the impact of socioeconomic status and sibling number on Helicobacter pylori infection has not been well studied in Japan. We conducted a cross-sectional study to evaluate the impact of socioeconomic status, represented by education level, and sibling number on the prevalence of Helicobacter pylori infection among 3,423 non-cancer subjects who visited Aichi Cancer Center between 2005 and 2013. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a logistic regression model adjusted for potential confounding variables. Of the 3,423 subjects, 1,459 (42.6%) were Helicobacter pylori-positive. The prevalence of Helicobacter pylori infection linearly decreased with increasing socioeconomic status [ORs (95% CIs) of moderate and high socioeconomic status relative to low socioeconomic status of 0.67 (0.53–0.84) and 0.43 (0.34–0.54), respectively; P trend=9.7×10^–17 ]. In contrast, the prevalence of Helicobacter pylori infection linearly increased with increasing sibling number [ORs (95% CIs) of SN 3–4 and ≥5 relative to sibling number ≤2 of 1.74 (1.47–2.06) and 2.54 (2.12–3.04), respectively; P trend=1.2×10^–24 ]. This study showed that socioeconomic status and sibling number were significantly associated with the prevalence of Helicobacter pylori infection.},
 pages = {374--387},
 title = {Impact of socioeconomic status and sibling number on the prevalence of Helicobacter pylori infection: a cross-sectional study in a Japanese population},
 volume = {84},
 year = {2022}
}