@article{oai:nagoya.repo.nii.ac.jp:02004207,
 author = {Sobue, Yasumori and Suzuki, Mochihito and Ohashi, Yoshifumi and Koshima, Hiroshi and Okui, Nobuyuki and Funahashi, Koji and Ishikawa, Hisato and Inoue, Hidenori and Kojima, Masayo and Asai, Shuji and Terabe, Kenya and Hattori, Kyosuke and Kishimoto, Kenji and Takahashi, Nobunori and Imagama, Shiro and Kojima, Toshihisa},
 issue = {4},
 journal = {Nagoya Journal of Medical Science},
 month = {Nov},
 note = {This study aimed to longitudinally evaluate the development of locomotive syndrome (LS) in rheumatoid arthritis (RA) patients during the COVID-19 pandemic using the 25-question Geriatric Locomotive Function Scale (GLFS-25). Subjects were 286 RA patients (female, 70.6%; mean age, 64.2 years) who had GLFS-25 and Clinical Disease Activity Index (CDAI) data available for a 1-year period during the COVID-19 pandemic and who did not have LS at baseline. Associations between subject characteristics and development of LS were determined using logistic regression analysis. Among the 286 patients, 38 (13.3%, LS group) developed LS at 1 year after baseline. In the LS group, scores of the GLFS-25 categories “GLFS-5” and “Social activities” were significantly increased at 1 year relative to baseline. GLFS-5 is a quick 5-item version of the GLFS-25, including questions regarding the difficulty of going up and down stairs, walking briskly, distance able to walk without rest, difficulty carrying objects weighing 2 kg, and ability to carry out load-bearing tasks and housework. A significant correlation was also observed between changes in “Social activities” and that of “GLFS-5.” Multivariable logistic regression analysis revealed that the development of LS was significantly associated with BMI (OR: 1.11 [95% confidence interval (CI): 1.00–1.22]) and CDAI (OR: 1.08 [95%CI: 1.00–1.16]) at baseline. Adequate exercise and tight control of RA disease activity are important for preventing the development of LS in view of restrictions on going out imposed during the COVID-19 pandemic. GLFS-5 is useful for evaluating the physical function of RA patients.},
 pages = {799--812},
 title = {Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic},
 volume = {84},
 year = {2022}
}