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Study design: This was a population-based retrospective study of preterm infants weighing ≤ 1500 g born between 22 and 31 weeks of gestation between 2003 and 2017. After 1:1 stratification matching by four factors (maternal age, gestational age, parity, and year of delivery), a total of 5137 infants in each group (HDP and non-HDP groups) were selected. Main outcome measures: The association between HDP and various respiratory outcomes was evaluated using univariate and multivariate logistic regression analyses. Results: In the multivariate analyses, HDP was associated with higher odds for respiratory distress syndrome (RDS) (odds ratio 1.83, 95% confidence interval [1.65–2.03]), but reduced odds of persistent pulmonary hypertension of the newborn (PPHN) (0.34 [0.26–0.46]) and inhaled nitric oxide use (0.43 [0.33–0.55]). 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan

http://hdl.handle.net/2237/0002004247
http://hdl.handle.net/2237/0002004247
f3114df3-427a-420d-a26a-b22ab8aa45de
名前 / ファイル ライセンス アクション
HDP_and_respiratory_outcomes_2022_5_28.pdf HDP_and_respiratory_outcomes_2022_5_28.pdf (581 KB)
 Download is available from 2023/7/31.
Item type itemtype_ver1(1)
公開日 2022-12-01
タイトル
タイトル Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan
言語 en
著者 Ushida, Takafumi

× Ushida, Takafumi

en Ushida, Takafumi

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Nakamura, Noriyuki

× Nakamura, Noriyuki

en Nakamura, Noriyuki

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Nakatochi, Masahiro

× Nakatochi, Masahiro

en Nakatochi, Masahiro

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Kobayashi, Yumiko

× Kobayashi, Yumiko

en Kobayashi, Yumiko

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Sato, Yoshiaki

× Sato, Yoshiaki

en Sato, Yoshiaki

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Iitani, Yukako

× Iitani, Yukako

en Iitani, Yukako

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Imai, Kenji

× Imai, Kenji

en Imai, Kenji

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Nakano-Kobayashi, Tomoko

× Nakano-Kobayashi, Tomoko

en Nakano-Kobayashi, Tomoko

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Hayakawa, Masahiro

× Hayakawa, Masahiro

en Hayakawa, Masahiro

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Kajiyama, Hiroaki

× Kajiyama, Hiroaki

en Kajiyama, Hiroaki

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Kotani, Tomomi

× Kotani, Tomomi

en Kotani, Tomomi

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Neonatal Research Network of Japan

× Neonatal Research Network of Japan

en Neonatal Research Network of Japan

Search repository
アクセス権
アクセス権 embargoed access
アクセス権URI http://purl.org/coar/access_right/c_f1cf
権利
言語 en
権利情報 © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述 Objectives: We aimed to evaluate the impact of hypertensive disorders of pregnancy (HDP) on short- and medium-term respiratory outcomes in extremely and very preterm infants using the Neonatal Research Network of Japan database. Study design: This was a population-based retrospective study of preterm infants weighing ≤ 1500 g born between 22 and 31 weeks of gestation between 2003 and 2017. After 1:1 stratification matching by four factors (maternal age, gestational age, parity, and year of delivery), a total of 5137 infants in each group (HDP and non-HDP groups) were selected. Main outcome measures: The association between HDP and various respiratory outcomes was evaluated using univariate and multivariate logistic regression analyses. Results: In the multivariate analyses, HDP was associated with higher odds for respiratory distress syndrome (RDS) (odds ratio 1.83, 95% confidence interval [1.65–2.03]), but reduced odds of persistent pulmonary hypertension of the newborn (PPHN) (0.34 [0.26–0.46]) and inhaled nitric oxide use (0.43 [0.33–0.55]). Although HDP was associated with an increased risk of chronic lung disease (CLD) in the univariate analysis, this association was not significant after adjustment for covariates (0.94 [0.83–1.07]). No significant association was found between HDP and home oxygen therapy (HOT) and medium-term oxygen use. Conclusion: The impact of maternal HDP largely differed depending on respiratory disorders and respiratory support. HDP was associated with higher odds of RDS but reduced odds of PPHN. The risks for CLD, HOT, and medium-term respiratory outcomes in the HDP group were comparable to those in the non-HDP group.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.preghy.2022.06.003
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 22107789
書誌情報 en : Pregnancy Hypertension

巻 29, p. 54-60, 発行日 2022-08
ファイル公開日
日付 2023-08-01
日付タイプ Available
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