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  1. I100 総合保健体育科学センター
  2. I100b 紀要
  3. 総合保健体育科学
  4. 22(1)

一酸化窒素(NO)のインスリン作用に及ぼす効果 : euglycemic clamp法を用いた検討

https://doi.org/10.18999/njhpfs.22.1.53
https://doi.org/10.18999/njhpfs.22.1.53
92f53088-9b56-4aef-833d-95caf8cd0d9e
名前 / ファイル ライセンス アクション
njhpfs_22_1_53.pdf njhpfs_22_1_53.pdf (2.8 MB)
Item type itemtype_ver1(1)
公開日 2023-03-30
タイトル
タイトル 一酸化窒素(NO)のインスリン作用に及ぼす効果 : euglycemic clamp法を用いた検討
言語 ja
その他のタイトル
その他のタイトル Effect of nitric oxide on insulin action in STZ-induced diabetic rats
言語 en
著者 李, 玲

× 李, 玲

ja 李, 玲

en LI, Ling

Search repository
押田, 芳治

× 押田, 芳治

ja 押田, 芳治

en OSHIDA, Yoshiharu

Search repository
韓, 艶清

× 韓, 艶清

ja 韓, 艶清

en HAN, Yanqing

Search repository
北越, 香織

× 北越, 香織

ja 北越, 香織

en KITAKOSHI, Kaori

Search repository
福, 典之

× 福, 典之

ja 福, 典之

en FUKU, Noriyuki

Search repository
佐藤, 祐造

× 佐藤, 祐造

ja 佐藤, 祐造

en SATO, Yuzo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
内容記述
内容記述 The present study was undertaken to determine the influence of nitric oxide (NO) on in vivo glucose utilization in STZ-induced diabetic rats using the euglycemic clamp technique. Insulin was infused at a rate of 3.0 mU/kg/min in the awake condition. Sodium nitroprusside (SNP), which was nitric oxide donor, and adenosine, which is NO independent vasodilator, were also given at a rate of 3ng/kg/min, and 1.5μmol/kg/min, respectively, during the euglycemic insulin clamp. Plasma insulin levels during the insulin infusion were 30μU/ml, and blood glucose was clamped at 140 mg/dl by periodic adjustment of i.v. glucose infusion rate. Metabolic clearance rate of glucose (MCR) in diabetic rats given SNP during the insulin clamp was 15.6 ± 1.7 ml/kg/min, as compared to 8.3 ± 0.8 ml/kg/min in diabetic control rats (p < 0.05), and reached to 83% of level of normal rats (18.8 ± 2.7 ml/kg/min). MCR in diabetic rats infused with adenosine (7.1 ± 0.8) was similar to diabetic conntrol rats. It could be concluded that NO stimulates whole body glucose utilization in diabetic rats.
言語 en
内容記述タイプ Abstract
出版者
言語 ja
出版者 名古屋大学総合保健体育科学センター
出版者
言語 en
出版者 The Research Center of Health, Physical Fitness and Sports, Nagoya University
言語
言語 jpn
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/njhpfs.22.1.53
ID登録タイプ JaLC
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0289-5412
書誌情報 ja : 総合保健体育科学
en : Nagoya Journal of Health, Physical Fitness & Sports

巻 22, 号 1, p. 53-56, 発行日 1999-03-31
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