@article{oai:nagoya.repo.nii.ac.jp:02005253,
 author = {李, 玲 and LI, Ling and 押田, 芳治 and OSHIDA, Yoshiharu and 韓, 艶清 and HAN, Yanqing and 北越, 香織 and KITAKOSHI, Kaori and 福, 典之 and FUKU, Noriyuki and 佐藤, 祐造 and SATO, Yuzo},
 issue = {1},
 journal = {総合保健体育科学, Nagoya Journal of Health, Physical Fitness & Sports},
 month = {Mar},
 note = {The present study was undertaken to determine the influence of nitric oxide (NO) on in vivo glucose utilization in STZ-induced diabetic rats using the euglycemic clamp technique. Insulin was infused at a rate of 3.0 mU/kg/min in the awake condition. Sodium nitroprusside (SNP), which was nitric oxide donor, and adenosine, which is NO independent vasodilator, were also given at a rate of 3ng/kg/min, and 1.5μmol/kg/min, respectively, during the euglycemic insulin clamp. Plasma insulin levels during the insulin infusion were 30μU/ml, and blood glucose was clamped at 140 mg/dl by periodic adjustment of i.v. glucose infusion rate. Metabolic clearance rate of glucose (MCR) in diabetic rats given SNP during the insulin clamp was 15.6 ± 1.7 ml/kg/min, as compared to 8.3 ± 0.8 ml/kg/min in diabetic control rats (p < 0.05), and reached to 83% of level of normal rats (18.8 ± 2.7 ml/kg/min). MCR in diabetic rats infused with adenosine (7.1 ± 0.8) was similar to diabetic conntrol rats. It could be concluded that NO stimulates whole body glucose utilization in diabetic rats.},
 pages = {53--56},
 title = {一酸化窒素(NO)のインスリン作用に及ぼす効果 : euglycemic clamp法を用いた検討},
 volume = {22},
 year = {1999}
}