@article{oai:nagoya.repo.nii.ac.jp:02005303,
 author = {李, 玲 and LI, Ling and 押田, 芳治 and OSHIDA, Yoshiharu and 羅, 偉権 and LUO, Weiquan and 大竹, 康敬 and OHTAKE, Yasutake and JOHANSSON, Bo-Lennart and WAHREN, John and 矢内原, 昇 and YANAIHARA, Noboru and 佐藤, 祐造 and SATO, Yuzo},
 issue = {1},
 journal = {総合保健体育科学, Nagoya Journal of Health, Physical Fitness & Sports},
 month = {Mar},
 note = {Our previous studies suggest that C-peptide augments glucose utilization in strepotozotocin (STZ)-induced diabetic rats. The present study was undertaken to determine the influence of human C-peptide fragment (11-22) on in vivo glucose utilization in STZ-induced diabetic rats by using the sequential euglycemic clamp technique. Two different insulin infusion rates, 3.0 (low-dose) and 30.0 (high-dose) mU/kg/min were employed in the awake condition. Rat C-peptide I or human C-peptide fragment was infused at a rate of 0.05 nmol/kg/min, which increased plasma levels from 0.2 ± 0.1 to 12.3 ± 5.2 ng/ml, from 0.6 ± 0.1 to 22.5 ± 2.2 ng/ml, respectively. (fasting levels in controls were 4.7 ± 1.0 ng/ml). Plasma insulin level during the low-dose and high-dose insulin infusion were 30 and 400 μU/ml, respectively, and blood glucose was clamped at 140 mg/dl by periodic adjustment of i.v. glucose infusion rate. Glucose metabolic clearance rate (MCR) in diabetic rats given rat C-peptide I during the low-dose insulin clamp was 17.4 ± 2.9 ml/kg/min (n = 6) as compared to 8.3 ± 0.7 ml/kg/min (n = 6) in diabetic control rats (p<0.05). Likewise, MCR in diabetic rats infused with human C-peptide fragment (11-22) (13.0 ± 3.2) tended to be 50% greater than in control diabetic rats, but not statistically significant. Rat C-peptide I and human C-peptide fragment (11-22) did not significantly influence MCR at the high-dose insulin clamps. It could be concluded that human C-peptide fragment (11-22) also has biological activity in glucose utilization.},
 pages = {21--25},
 title = {C-ペプチドフラグメントのインスリン作用に及ぼす影響},
 volume = {21},
 year = {1998}
}