{"created":"2023-04-03T01:36:06.422383+00:00","id":2005303,"links":{},"metadata":{"_buckets":{"deposit":"3246bbc6-d17f-4d3b-9be4-0e932269634b"},"_deposit":{"id":"2005303","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2005303"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02005303","sets":["1213:1620:1621:1680485626845"]},"author_link":[],"control_number":"2005303","item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effect of C-peptide fragment on insulin action in STZ-induced diabetic rats","subitem_alternative_title_language":"en"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"21","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"総合保健体育科学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Nagoya Journal of Health, Physical Fitness & Sports","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Our previous studies suggest that C-peptide augments glucose utilization in strepotozotocin (STZ)-induced diabetic rats. The present study was undertaken to determine the influence of human C-peptide fragment (11-22) on in vivo glucose utilization in STZ-induced diabetic rats by using the sequential euglycemic clamp technique. Two different insulin infusion rates, 3.0 (low-dose) and 30.0 (high-dose) mU/kg/min were employed in the awake condition. Rat C-peptide I or human C-peptide fragment was infused at a rate of 0.05 nmol/kg/min, which increased plasma levels from 0.2 ± 0.1 to 12.3 ± 5.2 ng/ml, from 0.6 ± 0.1 to 22.5 ± 2.2 ng/ml, respectively. (fasting levels in controls were 4.7 ± 1.0 ng/ml). Plasma insulin level during the low-dose and high-dose insulin infusion were 30 and 400 μU/ml, respectively, and blood glucose was clamped at 140 mg/dl by periodic adjustment of i.v. glucose infusion rate. Glucose metabolic clearance rate (MCR) in diabetic rats given rat C-peptide I during the low-dose insulin clamp was 17.4 ± 2.9 ml/kg/min (n = 6) as compared to 8.3 ± 0.7 ml/kg/min (n = 6) in diabetic control rats (p<0.05). Likewise, MCR in diabetic rats infused with human C-peptide fragment (11-22) (13.0 ± 3.2) tended to be 50% greater than in control diabetic rats, but not statistically significant. Rat C-peptide I and human C-peptide fragment (11-22) did not significantly influence MCR at the high-dose insulin clamps. It could be concluded that human C-peptide fragment (11-22) also has biological activity in glucose utilization.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/njhpfs.21.1.21","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"名古屋大学総合保健体育科学センター","subitem_publisher_language":"ja"},{"subitem_publisher":"The Research Center of Health, Physical Fitness and Sports, Nagoya University","subitem_publisher_language":"en"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0289-5412","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"李, 玲","creatorNameLang":"ja"},{"creatorName":"LI, Ling","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"押田, 芳治","creatorNameLang":"ja"},{"creatorName":"OSHIDA, Yoshiharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"羅, 偉権","creatorNameLang":"ja"},{"creatorName":"LUO, Weiquan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大竹, 康敬","creatorNameLang":"ja"},{"creatorName":"OHTAKE, Yasutake","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"JOHANSSON, Bo-Lennart","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"WAHREN, John","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"矢内原, 昇","creatorNameLang":"ja"},{"creatorName":"YANAIHARA, Noboru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 祐造","creatorNameLang":"ja"},{"creatorName":"SATO, Yuzo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"displaytype":"detail","filename":"njhpfs_21_1_21.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2005303/files/njhpfs_21_1_21.pdf"},"version_id":"cbbc5a18-5127-4d8e-86c4-c34a42f199df"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"C-ペプチドフラグメントのインスリン作用に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C-ペプチドフラグメントのインスリン作用に及ぼす影響","subitem_title_language":"ja"}]},"item_type_id":"40001","owner":"1","path":["1680485626845"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"2005303","relation_version_is_last":true,"title":["C-ペプチドフラグメントのインスリン作用に及ぼす影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-04-04T00:22:55.797104+00:00"}