@article{oai:nagoya.repo.nii.ac.jp:02005386,
 author = {OHSAWA, Isao and SATO, Juichi and OSHIDA, Yoshiharu and SATO, Yuzo},
 issue = {1},
 journal = {総合保健体育科学, Nagoya Journal of Health, Physical Fitness & Sports},
 month = {Mar},
 note = {To evaluate the effects of physical exercise on insulin resistance associated with aging, we investigated insulin-induced glucose disposal in mature trained rats (MT, 4 months of age), mature untrained ones (MU, 4 months of age), and young untrained ones (YU, 2 months of age), using the 2-step sequential euglycemic clamp technique (insulin infusion rates: 6 and 30 mU/kg/min). During 30 mU/kg/min clamp, metabolic clearance rates of glucose (MCR) in MU significantly declined compared with YU (P<0.01). MCR during 6 and 30 mU/kg/min clamp were, respectively, significantly higher in MT than in MU (P<0.01). There were no significant differences in MCR between MT and YU. These results suggest that aging process of rats might decrease insulin action in their peripheral tissues predominantly because of post insulin receptor binding defect, and that physical exercise begun before maturity might prevent or delay insulin resistance associated with aging.},
 pages = {53--58},
 title = {Physical exercise started before maturity prevents aging-related insulin resistance in rats},
 volume = {20},
 year = {1997}
}