@article{oai:nagoya.repo.nii.ac.jp:02005847,
 author = {佐藤, 祐造 and SATO, Yuzo and 押田, 芳治 and OSHIDA, Yoshiharu and 大沢, 功 and OHSAWA, Isao and 佐藤, 寿一 and SATO, Juichi and 山之内. 国男 and YAMANOUCHI, Kunio and 樋口, 満 and HIGUCHI, Mitsuru and 小林, 修平 and KOBAYASHI, Shuhei and 篠田, 廣 and SHINODA, Hiroshi},
 issue = {1},
 journal = {総合保健体育科学, Nagoya Journal of Health, Physical Fitness & Sports},
 month = {Mar},
 note = {Previous studies have shown that physical training improves carbohydrate metabolism. The purpose of this study was to evaluate the effects of physical training on the insulin action using the euglycemic clamp technique. The rate of insulin-mediated glucose uptake (glucose metabolism, GM) in 16 simple obese subjects (3.7±0.5mg/kg/min) and 18 obese diabetics (3.3±0.3mg/kg/min) were significantly (P<0.001) lower than those in 32 healthy controls (7.3±0.2mg/kg/min), whose values were, on the other hand, significantly (P<0.001) lower than those in 22 athletes (10.5±0.5mg/kg/min). GM in the 9 aged subjects (6.7±0.8mg/kg/min) was lower than that in young controls. In the glucose metabolic clearance rate (MCR), which was measured because of different fasting plasma glucose concentrations, the same significant changes were found in above these subjects. A positive correlation was observed between GM and V02max, while a strong inverse correlation existed between GM and BMI (r=0.841, P<0.001). MCR during regular-dose clamp in 10 young athletes (12.8±1.0ml/kg/min) was significantly higher (P<0.05) than those in 10 young untrained controls (9.0±0.7ml/kg/min), 13 aged untrained subjects (6.7±0.9ml/kg/min) and 10 aged trained athletes. MCR in aged athletes was significantly higher than that in aged untrained subjects. MCR during high-dose clamp in 10 aged untrained subjects (11.2±1.2ml/kg/min) was significantly lower (P<0.05) than those in 5 young untrained controls (17.8±1.7ml/kg/min), 5 young trained athletes (16.2±0.8ml/kg/min) and 5 aged trained athletes (18.5±l.2ml/kg/min). However no significant correlation could be observed between the latter 3 groups. These results might suggest that (1) the euglycemic clamp procedure provides a reliable estimate for training effects, and (2) physical training increases insulin sensitivity in young trained athletes and insulin responsiveness in aged athletes.},
 pages = {9--14},
 title = {トレーニング効果の生化学的評価 : multiple euglycemic clamp法を用いて},
 volume = {14},
 year = {1991}
}