@article{oai:nagoya.repo.nii.ac.jp:02006067,
 author = {早水, サヨ子 and HAYAMIZU, Sayoko and 佐藤, 祐造 and SATO, Yuzo and 山本, 親 and YAMAMOTO, Chikashi and 大桑, 哲男 and OHKUWA, Tetsuo and 戸田, 安士 and TODA, Yasushi and 伊藤, 章 and ITO, Akira},
 issue = {1},
 journal = {総合保健体育科学, Nagoya Journal of Health, Physical Fitness & Sports},
 month = {Mar},
 note = {Physical exercise has been considered benefical in the treatment of diabetes for many years. In poorly controlled, especially, ketotic diabetics, however, physical exercise results in more pronounced hyperglycemia, hyperlipidemia and hyperketonemia. But the mechanism of physical exercise has never been studied in detail. This study was performed to clarify the effect of physical exercise on the metabolic and hormonal changes in patients with diabetes mellitus in order to establish the biochemical criteria of physical exercise treatment. 100g glucose was administered to 5 healthy subjects, 4 mild and 4 severe diabetics. Furthermore, exercise-glucose tolerance tests were carried out using treadmill walking with a speed of 70 m/min for 30 minutes during 60 to 90 minutes following oral administration of 100g glucose, and the data were compared respectively with those of glucose tolerance tests. The magnitude of decrease of blood glucose and insulin levels tended to be lower in the severe diabetics than in the mild diabetics, and also, to be lower in the mild diabetics than in the healthy subjects. In contrast, the total ketone body concentrations increased 30 minutes after exercise in severe diabetics. Physical exercise did not produce any significant changes in the other metabolites and hormones. In one of the severe diabetics whose insulin values remained at a low level, physical exercise became a stressor and the hypercaloraemic state induced further hypercaloraemia, because the blood glucose, FFA and total ketone body levels increased after exercise. It is concluded that only well controlled diabetic patients can participate in physical exercise treatment, confirming that insulin may exert a permissive effect on exercise-induced glucose uptake.},
 pages = {63--71},
 title = {代謝性疾患の運動療法に関する研究 第二報 : 糖尿病者の軽運動負荷時における代謝変動},
 volume = {6},
 year = {1983}
}