{"created":"2023-08-30T05:42:11.529906+00:00","id":2007122,"links":{},"metadata":{"_buckets":{"deposit":"ee5ff599-bac8-4189-b175-57279477bd92"},"_deposit":{"created_by":17,"id":"2007122","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2007122"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02007122","sets":["499:508:509:1693372917749"]},"author_link":[],"control_number":"2007122","item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"427","bibliographicPageStart":"402","bibliographicVolumeNumber":"85","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Ustekinumab has recently been approved for the treatment of ulcerative colitis (UC) based on data from clinical trials. However, the effectiveness of ustekinumab in patients with UC in a real-world setting remains unclear. Hence, in this meta-analysis, we aimed to evaluate the effectiveness of ustekinumab in a real-world setting and to investigate the predictors of its effectiveness. A comprehensive literature search was performed to examine the effectiveness of ustekinumab in UC patients admitted between January 2019 and December 2021. Data on clinical remission, response, and corticosteroid-free clinical remission rates were extracted, pooled, and analyzed. Meta-regression analysis was performed to investigate the source of heterogeneity and the impact of moderators on the outcomes of interest. A total of 14 eligible studies were identified. The pooled clinical remission rate was 55.0% at week 8, 36.1% at week 16, 46.6% at month 6, and 38.6% at month 12. The meta-regression analysis showed that prior use of anti-tumor necrosis factor (TNF) agents and vedolizumab and the publication style were significant moderators. Additionally, out of 258 patients, there were 28 adverse events (AEs) (10.9%). The effectiveness of ustekinumab in real-world patients with UC was consistent with the results clinical trials. Moreover, previous treatment with anti-TNF agents and vedolizumab might have affected the effectiveness of ustekinumab.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.85.3.402","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/853.html","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uchida, Genta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Masanao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamura, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsuzuki, Tomoyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawashima, Hiroki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-30"}],"displaytype":"detail","filename":"01_Uchida.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2007122/files/01_Uchida.pdf"},"version_id":"0afae6e4-b6a1-4ba9-9719-1702b99c98e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ustekinumab","subitem_subject_scheme":"Other"},{"subitem_subject":"ulcerative colitis","subitem_subject_scheme":"Other"},{"subitem_subject":"systematic review","subitem_subject_scheme":"Other"},{"subitem_subject":"meta-analysis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["1693372917749"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-30"},"publish_date":"2023-08-30","publish_status":"0","recid":"2007122","relation_version_is_last":true,"title":["Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-08-30T06:13:11.146948+00:00"}