{"_buckets": {"deposit": "cc998f01-0f6e-44f2-81ed-4524c925bffa"}, "_deposit": {"created_by": 17, "id": "2007323", "owner": "17", "owners": [17], "owners_ext": {"displayname": "repository", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2007323"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02007323"}, "author_link": [], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2024-04-17", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2023-04-17", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "104", "bibliographicPageStart": "91", "bibliographicVolumeNumber": "57", "bibliographic_titles": [{"bibliographic_title": "Free Radical Research", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Cold atmospheric pressure plasmas are promising medical tools that can assist in cancer treatment. While the medical pathology mechanism is substantially understood, knowledge of the contribution of reactive species formed in plasma and the mode of activation of biochemical pathways is insufficient. Herein, we present a concept involving antitumoral plasma-activated organics, which is envisaged to increase cytotoxicity levels against cancer cells. Ringer′s acetate solution was irradiated by low-temperature plasma at atmospheric pressure and possible reaction pathways of the compound generation are presented. The chemical compounds formed by plasma treatment and their effects on non-tumorigenic breast epithelial cells (MCF-10A) and breast cancer cells (MCF-7) were investigated. The cell viability results have shown that plasma-derived compounds have both, stimulatory and inhibitory effects on cell viability, depending on the concentration of the generated compounds in the irradiated liquids. Previous studies have shown that oxidative stresses involving reactive oxygen and nitrogen species (RONS) can be used to kill cancer cells. Hence, while RONS offers promising first-step killing effects, cell viability results have shown that plasma-derived compounds, such as acetic anhydride and ethyl acetate, have the potential to play important roles in plasma-based cancer therapy.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Taylor \u0026 Francis", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1080/10715762.2023.2201390", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is an Accepted Manuscript of an article published by Taylor \u0026 Francis Group in Free Radical Research on 17/04/2023, available online: http://www.tandfonline.com/10.1080/10715762.2023.2201390.", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "1071-5762", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "embargoed access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_f1cf"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Miron, Camelia", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Kenji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kashiwagura, Satoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Suda, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Hiromasa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakamura, Kae", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kajiyama, Hiroaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Toyokuni, Shinya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mizuno, Masaaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hori, Masaru", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2024-04-17"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2024/4/16.", "file_order": 0, "filename": "IFRA2201390.pdf", "filesize": [{"value": "4.1 MB"}], "format": "application/pdf", "future_date_message": "Download is available from 2024/4/16.", "is_thumbnail": false, "mimetype": "application/pdf", "size": 4099999.9999999995, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2007323/files/IFRA2201390.pdf"}, "version_id": "f3833c53-9b51-4f82-9e5b-26134861aa65"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["1652159861261"], "permalink_uri": "http://hdl.handle.net/2237/0002007323", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-09-14"}, "publish_date": "2023-09-14", "publish_status": "0", "recid": "2007323", "relation": {}, "relation_version_is_last": true, "title": ["Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma"], "weko_shared_id": -1}