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Although endoscopic injection sclerotherapy (EIS) with ethanolamine oleate (EO) is reported useful for children, risk factors associated with the presence of high-risk EGVs after treatment remain unknown. Methods: The subjects were BA patients under 15 years of age who underwent EO-EIS. We retrospectively reviewed a total of 28 treatment sessions of EGVs with red signs and those larger than F2, which were considered to be at high risk of bleeding. Survival analysis was performed for the presence of high-risk EGVs at the time of follow-up endoscopy as the occurrence of an event. Results: Univariate analysis showed a significantly increased risk of the presence of high-risk EGVs post-EO-EIS in patients with increased liver stiffness (LS) and Mac-2 binding protein glycan isomer (M2BPGi), with hazard ratios of 1.48 and 1.15, respectively. The median presence-free period was significantly shorter in the LS ≥ 2.8 m/s patients than in those with LS \u003c2.8 m/s (189 vs. 266 days). Similarly, the median presence-free period was significantly shorter in patients with M2BPGi ≥ 4.0 than in those with M2BPGi \u003c 4.0 (182 vs. 203 days). The results of multivariate analysis revealed that the risk of the presence of high-risk EGVs was significantly higher only in the high-LS group, with a hazard ratio of 2.76. 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

The presence of high‐risk varices after sclerotherapy in biliary atresia

http://hdl.handle.net/2237/0002007329
http://hdl.handle.net/2237/0002007329
4150f1d3-149a-42e2-aed6-be9b8750a68f
名前 / ファイル ライセンス アクション
PED-00659-2022.R1_Proof_hi.pdf PED-00659-2022.R1_Proof_hi.pdf (741 KB)
 Download is available from 2023/12/20.
Item type itemtype_ver1(1)
公開日 2023-09-14
タイトル
タイトル The presence of high‐risk varices after sclerotherapy in biliary atresia
言語 en
著者 Yokoyama, Shinya

× Yokoyama, Shinya

en Yokoyama, Shinya

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Ishizu, Yoji

× Ishizu, Yoji

en Ishizu, Yoji

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Honda, Takashi

× Honda, Takashi

en Honda, Takashi

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Imai, Norihiro

× Imai, Norihiro

en Imai, Norihiro

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Ito, Takanori

× Ito, Takanori

en Ito, Takanori

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Yamamoto, Kenta

× Yamamoto, Kenta

en Yamamoto, Kenta

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Shirota, Chiyoe

× Shirota, Chiyoe

en Shirota, Chiyoe

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Tainaka, Takahisa

× Tainaka, Takahisa

en Tainaka, Takahisa

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Sumida, Wataru

× Sumida, Wataru

en Sumida, Wataru

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Makita, Satoshi

× Makita, Satoshi

en Makita, Satoshi

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Takimoto, Aitaro

× Takimoto, Aitaro

en Takimoto, Aitaro

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Nakagawa, Yoichi

× Nakagawa, Yoichi

en Nakagawa, Yoichi

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Takada, Shunya

× Takada, Shunya

en Takada, Shunya

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Ishigami, Masatoshi

× Ishigami, Masatoshi

en Ishigami, Masatoshi

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Uchida, Hiroo

× Uchida, Hiroo

en Uchida, Hiroo

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Kawashima, Hiroki

× Kawashima, Hiroki

en Kawashima, Hiroki

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アクセス権
アクセス権 embargoed access
アクセス権URI http://purl.org/coar/access_right/c_f1cf
権利
言語 en
権利情報 "This is the peer reviewed version of the following article: [Yokoyama, S, Ishizu, Y, Honda, T, Imai, N, Ito, T, Yamamoto, K, et al. The presence of high-risk varices after sclerotherapy in biliary atresia. Pediatr Int. 2023; 64:e15454. https://doi.org/10.1111/ped.15454], which has been published in final form at [https://doi.org/10.1111/ped.15454]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."
内容記述
内容記述 Background: Esophagogastric varices (EGVs) may develop as a result of portal hypertension in children with biliary atresia (BA). Although endoscopic injection sclerotherapy (EIS) with ethanolamine oleate (EO) is reported useful for children, risk factors associated with the presence of high-risk EGVs after treatment remain unknown. Methods: The subjects were BA patients under 15 years of age who underwent EO-EIS. We retrospectively reviewed a total of 28 treatment sessions of EGVs with red signs and those larger than F2, which were considered to be at high risk of bleeding. Survival analysis was performed for the presence of high-risk EGVs at the time of follow-up endoscopy as the occurrence of an event. Results: Univariate analysis showed a significantly increased risk of the presence of high-risk EGVs post-EO-EIS in patients with increased liver stiffness (LS) and Mac-2 binding protein glycan isomer (M2BPGi), with hazard ratios of 1.48 and 1.15, respectively. The median presence-free period was significantly shorter in the LS ≥ 2.8 m/s patients than in those with LS <2.8 m/s (189 vs. 266 days). Similarly, the median presence-free period was significantly shorter in patients with M2BPGi ≥ 4.0 than in those with M2BPGi < 4.0 (182 vs. 203 days). The results of multivariate analysis revealed that the risk of the presence of high-risk EGVs was significantly higher only in the high-LS group, with a hazard ratio of 2.76. Conclusions: Increased LS is associated with risk of the presence of high-risk EGVs following EO-EIS in children with BA.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 First published: 21 December 2022
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/ped.15454
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1328-8067
書誌情報 en : Pediatrics International

巻 65, 号 1, p. e15454, 発行日 2023-12
ファイル公開日
日付 2023-12-01
日付タイプ Available
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