{"created":"2023-12-01T07:07:52.384847+00:00","id":2008446,"links":{},"metadata":{"_buckets":{"deposit":"2dd5e170-38fe-4bc8-83e0-5c3439164cb6"},"_deposit":{"created_by":17,"id":"2008446","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2008446"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02008446","sets":["499:508:509:1701410469907"]},"author_link":[],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1615768833594":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"18K08341","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08341/"},"subitem_award_titles":[{"subitem_award_title":"不適合HLA抗原を標的とした移植後再発に対するTCR導入T細胞療法の開発","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"21K08369","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08369/"},"subitem_award_titles":[{"subitem_award_title":"不適合HLA-DP抗原認識抗体を用いた移植後再発に対するCAR-T細胞の開発","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"796","bibliographicPageStart":"779","bibliographicVolumeNumber":"85","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Human leukocyte antigen (HLA)-DPB1 antigens are mismatched in approximately 70% of allogeneic hematopoietic stem cell transplantations (allo-HSCT) from HLA 10/10 matched unrelated donors. HLA-DP-mismatched transplantation was shown to be associated with an increase in acute graft-versus-host disease (GVHD) and a decreased risk of leukemia relapse due to the graft-versus-leukemia (GVL) effect. Immunotherapy targeting mismatched HLA-DP is considered reasonable to treat leukemia following allo-HCT if performed under non-inflammatory conditions. Therefore, we isolated CD4^+ T cell clones that recognize mismatched HLA-DPB1 from healthy volunteer donors and generated T cell receptor (TCR)-gene-modified T cells for future clinical applications. Detailed analysis of TCR-T cells expressing TCR from candidate clone #17 demonstrated specificity to myeloid and monocytic leukemia cell lines that even expressed low levels of targeted HLA-DP. However, they did not react to non-hematopoietic cell lines with a substantial level of targeted HLA-DP expression, suggesting that the TCR recognized antigenic peptide is only present in some hematopoietic cells. This study demonstrated that induction of T cells specific for HLA-DP, consisting of hematopoietic cell lineage-derived peptide and redirection of T cells with cloned TCR cDNA by gene transfer, is feasible when using careful specificity analysis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.85.4.779","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of 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Yoshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ichinohe, Tatsuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishikawa, Hiroyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Akatsuka, Yoshiki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-04"}],"displaytype":"detail","filename":"12_Katsuyama.pdf","filesize":[{"value":"4 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2008446/files/12_Katsuyama.pdf"},"version_id":"4fded24d-04ef-4b41-82eb-98f349614311"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TCR-T","subitem_subject_scheme":"Other"},{"subitem_subject":"GVHD","subitem_subject_scheme":"Other"},{"subitem_subject":"leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"allogeneic transplantation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"T cell receptor-engineered T cells derived from target human leukocyte antigen-DPB1-specific T cell can be a potential tool for therapy against leukemia relapse following allogeneic hematopoietic cell transplantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"T cell receptor-engineered T cells derived from target human leukocyte antigen-DPB1-specific T cell can be a potential tool for therapy against leukemia relapse following allogeneic hematopoietic cell transplantation","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["1701410469907"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-04"},"publish_date":"2023-12-04","publish_status":"0","recid":"2008446","relation_version_is_last":true,"title":["T cell receptor-engineered T cells derived from target human leukocyte antigen-DPB1-specific T cell can be a potential tool for therapy against leukemia relapse following allogeneic hematopoietic cell transplantation"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-12-04T05:13:13.095031+00:00"}