{"created":"2024-02-27T05:56:56.411176+00:00","id":2009347,"links":{},"metadata":{"_buckets":{"deposit":"b449af09-b300-4419-9d87-aef6f87caecc"},"_deposit":{"created_by":17,"id":"2009347","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2009347"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02009347","sets":["499:508:509:1709010820237"]},"author_link":[],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"154","bibliographicPageStart":"149","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The 22q11.2 deletion syndrome has many complications; one of them is immunodeficiency. However, the time of onset and the degree of immunodeficiency can vary. We report a case of a preterm infant with congenital cytomegalovirus infection complicated with 22q11.2 deletion syndrome and immunological abnormalities. Ultrasonography revealed pulmonary atresia, ventricular septal defect, major aortopulmonary collateral artery, and thymic hypoplasia. His serum chemistry tests on admission revealed immunoglobulin G, A, and M levels of 1,547 mg/dL, 70 mg/dL, and 274 mg/dL, respectively. A surface antigen analysis of the peripheral lymphocytes using flow cytometry revealed the following: relatively low CD4-positive T-cell levels (18.1%; 1,767/μL), very high CD8-positive T-cell levels (58.9%; 5,751/μL), and CD4/CD8 ratio of 0.31. The level of T-cell receptor excision circles was relatively low at 17.5 copies/μL. After birth, the CD8-positive T-cell level began to gradually decrease, whereas the CD4/CD8 ratio began to increase. Thrombocytopenia, neutropenia, and skin petechiae were observed on admission. However, the condition improved. Treatment for congenital cytomegalovirus infection was not provided due to the absence of viremia. Unfortunately, the patient died suddenly on the 158th day of life, and the cause of death was unknown. To the best of our knowledge, no association between 22q11 deletion syndrome and cCMV has been described in the recent medical literature. According to the calculation, around one newborn infant who have both 22q11 deletion syndrome and cCMV infection will be born each year in Japan. Healthcare providers should pay more attention to this medical situation in the future.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.86.1.149","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/861.html","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shitara, Yoshihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toyofuku, Etsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Doi, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mukai, Takeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kashima, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kakiuchi, Satsuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kato, Motohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Naoto","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-27"}],"displaytype":"detail","filename":"16_Shitara.pdf","filesize":[{"value":"430 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2009347/files/16_Shitara.pdf"},"version_id":"8fa20d14-4a5d-455f-b194-b6866886d1fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"22q11.2 deletion syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"congenital cytomegalovirus infection","subitem_subject_scheme":"Other"},{"subitem_subject":"immunological abnormalities","subitem_subject_scheme":"Other"},{"subitem_subject":"surface antigen analysis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["1709010820237"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-27"},"publish_date":"2024-02-27","publish_status":"0","recid":"2009347","relation_version_is_last":true,"title":["Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-02-28T01:02:28.093256+00:00"}