| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-05-22 |
| タイトル |
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タイトル |
Cobalt/Organophotoredox Dual-Catalysis-Enabled Cyclization of 1,5,10-Enediynes Involving Metallole-Mediated Remote C(sp3)–H Bond Activation Leading to Axially Chiral Aryl Alkenes |
|
言語 |
en |
| 著者 |
Yamada, Keiji
Koga, Nobuaki
Yasui, Takeshi
Yamamoto, Yoshihiko
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ACS Catalysis], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-DJA2WBEBKZU3DZWSZ6US].” |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Transition-metal-catalyzed C(sp3)–H functionalization has been much less investigated compared to C(sp2)–H functionalization because the site-selectivity control in C(sp3)–H bond activation is much more challenging than that in C(sp2)–H bond activation. Site-selective C(sp3)–H functionalization without the assistance of directing groups is highly desirable, because the installation and removal of directing groups are not required. Hence, cycloaddition through a site-selective C–H bond activation triggered by the formation of metallacycles, such as metalloles, is a highly atom- and step-economical method for synthesizing complex carbo- and heterocycles from simple unsaturated substrates. Herein, we report the cobalt/photoredox dual-catalysis-enabled cyclization of 1,5,10-enediynes via remote C(sp3)–H bond activation triggered by metallole formation, affording axially chiral aryl alkenes. Several control experiments and theoretical calculations suggest that the C(sp3)–H bond cleavage proceeds through σ-complex-assisted metathesis (σ-CAM) in the metallole intermediate. |
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言語 |
en |
| 出版者 |
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出版者 |
ACS Publications |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1021/acscatal.3c05848 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
2155-5435 |
| 書誌情報 |
en : ACS Catalysis
巻 14,
号 3,
p. 2049-2057,
発行日 2024-02-02
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| ファイル公開日 |
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|
日付 |
2025-02-02 |
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日付タイプ |
Available |
manuscript_1227.pdf (1.6 MB)
