| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-05-24 |
| タイトル |
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タイトル |
Investigation of the effects of tableting parameters on reliable quantitative terahertz spectroscopy |
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言語 |
en |
| 著者 |
Su, Yuan
Xu, Yang
Wang, Han
Ma, Te
Tsuchikawa, Satoru
Inagaki, Tetsuya
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00339-024-07302-3 |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Particle size ratio, tablet thickness, and compaction pressure are three important tableting parameters that affect the obtained tablet spectrum. In this study, the single-factor test and response surface analysis (RSM) were adopted to examine how these three parameters and their interactions affect the analytical measurements performed over terahertz time-domain spectroscopy (THz-TDS). Tablet samples were composed of a different percent (wt-%) of acetylsalicylic acid within microcrystalline cellulose. Results indicate that change in absorption coefficient was found to be more obvious for a larger particle size ratio. Thinner tablets were sensitive to absorption coefficient effects created as the transmitted THz radiation propagates through the tablet interfaces. Compression pressure has a limited effect on the absorption coefficient. The particle size ratio had the largest effect on the coefficient of correlation of the quantitative regression model, followed by the compaction pressure, and the tablet thickness. In this study, the optimized tableting parameters were determined: tablet thickness of 0.48 mm, particle size ratio of about 1:1, and compaction pressure of 30 MPa. Under this condition, the R2 of the quantitative regression model of acetylsalicylic acid content was 0.971 and 0.998 at the range of acetylsalicylic acid mass fraction between 10 and 90 wt-%, 1 and 30 wt-%, respectively. This study provides a method to effectively reduce the scattering effect of spectral detection of tablets by improving the sample’s properties, to provide a reference for enhancing the reliability and accuracy of quantitative measurements. |
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言語 |
en |
| 出版者 |
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出版者 |
Springer |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00339-024-07302-3 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0947-8396 |
| 書誌情報 |
en : Applied Physics A
巻 130,
号 2,
p. 139,
発行日 2024-01-30
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| ファイル公開日 |
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日付 |
2025-01-30 |
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日付タイプ |
Available |
Revised_manuscript_Applied_Physics_A.pdf (1.3 MB)
