| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-05-27 |
| タイトル |
|
|
タイトル |
Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the Japanese population |
|
言語 |
en |
| 著者 |
Otgonbayar, Gantsooj
Lo, Tzuyao
Hayashi, Yu
Furuta, Sho
Aleksic, Branko
Nawa, Yoshihiro
Kushima, Itaru
Kato, Hidekazu
Kimura, Hiroki
Ozaki, Norio
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
3q29 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
TM4SF19 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PAK2 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
schizophrenia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
autism spectrum disorder |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Psychiatric disorders are highly inheritable, and most psychiatric disorders exhibit genetic overlap. Recent studies associated the 3q29 recurrent deletion with schizophrenia (SCZ) and autism spectrum disorder (ASD). In this study, we investigated the association of genes in the 3q29 region with SCZ and ASD. TM4SF19 and PAK2 were chosen as candidate genes for this study based on evidence from previous research. We sequenced TM4SF19 and PAK2 in 437 SCZ cases, 187 ASD cases and 524 controls in the Japanese population. Through targeted sequencing, we identified 6 missense variants among the cases (ASD & SCZ), 3 missense variants among controls, and 1 variant common to both cases and controls; however, no loss-of-function variants were identified. Fisher’s exact test showed a significant association of variants in TM4SF19 among cases (p=0.0160). These results suggest TM4SF19 variants affect the etiology of SCZ and ASD in the Japanese population. Further research examining 3q29 region genes and their association with SCZ and ASD is thus needed. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
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|
ID登録 |
10.18999/nagjms.86.2.216 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/862.html |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 86,
号 2,
p. 216-222,
発行日 2024-05
|
06_Otgonbayar.pdf (621 KB)
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