| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-07-03 |
| タイトル |
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タイトル |
Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe |
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言語 |
en |
| 著者 |
Maekawa, Yasukichi
Matsui, Kotaro
Okamoto, Keisuke
Shimasaki, Takafumi
Ohtsuka, Hokuto
Tani, Motohiro
Ihara, Kunio
Aiba, Hirofumi
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00438-024-02107-8 |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
To understand the lifespan of higher organisms, including humans, it is important to understand lifespan at the cellular level as a prerequisite. So, fission yeast is a good model organism for the study of lifespan. To identify the novel factors involved in longevity, we are conducting a large-scale screening of long-lived mutant strains that extend chronological lifespan (cell survival in the stationary phase) using fission yeast. One of the newly acquired long-lived mutant strains (No.98 mutant) was selected for analysis and found that the long-lived phenotype was due to a missense mutation (92Phe → Ile) in the plb1^+ gene. plb1^+ gene in fission yeast is a nonessential gene encoding a homolog of phospholipase B, but its functions under normal growth conditions, as well as phospholipase B activity, remain unresolved. Our analysis of the No.98 mutant revealed that the plb1 mutation reduces the integrity of the cellular membrane and cell wall and activates Sty1 via phosphorylation. |
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言語 |
en |
| 出版者 |
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出版者 |
Springer |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00438-024-02107-8 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1617-4615 |
| 書誌情報 |
en : Molecular Genetics and Genomics
巻 299,
号 1,
p. 20,
発行日 2024-02-29
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| ファイル公開日 |
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日付 |
2025-02-28 |
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日付タイプ |
Available |
ForNagoyaRepository.pdf (1.6 MB)
