| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-07-04 |
| タイトル |
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タイトル |
Evaluation of 4D Flow MRI‐Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis |
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言語 |
en |
| 著者 |
Hyodo, Ryota
Takehara, Yasuo
Ishizu, Yoji
Nishida, Kazuki
Mizuno, Takashi
Ichikawa, Kazushige
Horiguchi, Ryota
Kurata, Nobuhiko
Ogura, Yasuhiro
Yokoyama, Shinya
Naganawa, Shinji
Jin, Ning
Ichiba, Yoshito
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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権利情報 |
"This is the peer reviewed version of the following article: [Hyodo, R., Takehara, Y., Ishizu, Y., Nishida, K., Mizuno, T., Ichikawa, K., Horiguchi, R., Kurata, N., Ogura, Y., Yokoyama, S., Naganawa, S., Jin, N. and Ichiba, Y. (2024), Evaluation of 4D Flow MRI-Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis. J Magn Reson Imaging. https://doi.org/10.1002/jmri.29357], which has been published in final form at [https://doi.org/10.1002/jmri.29357]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Portal vein thrombosis (PVT) is thought to arise from stagnant blood flow, yet conclusive evidence is lacking. Relative residence time (RRT) assessed using 4D Flow MRI may offer insight into portal flow stagnation. Purpose: To explore the relationship between RRT values and the presence of PVT in cirrhotic participants. Study Type: Prospective. Population: Forty-eight participants with liver cirrhosis (27 males, median age 67 years [IQR: 57–73]) and 20 healthy control participants (12 males, median age 45 years [IQR: 40–54]). Field Strength/Sequence: 3 T/4D Flow MRI. Assessment: Laboratory (liver and kidney function test results and platelet count) and clinical data (presence of tumors and other imaging findings), and portal hemodynamics derived from 4D Flow MRI (spatiotemporally averaged RRT [RRT-mean], flow velocity, and flow rate) were analyzed. Statistical Tests: We used multivariable logistic regression, adjusted by selected covariates through the Lasso method, to explore whether RRT-mean is an independent risk factor for PVT. The area under the ROC curve (AUC) was also calculated to assess the model's discriminative ability. P < 0.05 indicated statistical significance. Results: The liver cirrhosis group consisted of 16 participants with PVT and 32 without PVT. Higher RRT-mean values (odds ratio [OR] 11.4 [95% CI: 2.19, 118]) and lower platelet count (OR 0.98 per 1000 μL [95% CI: 0.96, 0.99]) were independent risk factors for PVT. The incorporation of RRT-mean (AUC, 0.77) alongside platelet count (AUC, 0.75) resulted in an AUC of 0.84. When including healthy control participants, RRT-mean had an adjusted OR of 12.4 and the AUC of the combined model (RRT-mean and platelet count) was 0.90. Data Conclusion: Prolonged RRT values and low platelet count were significantly associated with the presence of PVT in cirrhotic participants. RRT values derived from 4D Flow MRI may have potential clinical relevance in the management of PVT. Evidence Level: 2. Technical Efficacy: Stage 2 |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
First published: 15 March 2024 |
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言語 |
en |
| 出版者 |
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出版者 |
Wiley |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/jmri.29357 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1053-1807 |
| 書誌情報 |
en : Journal of Magnetic Resonance Imaging
発行日 2024-03-15
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| ファイル公開日 |
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日付 |
2025-03-15 |
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日付タイプ |
Available |
JMRI-2023-0016JK-EIC.pdf (502 KB)
