{"created":"2024-08-29T02:01:57.438691+00:00","id":2011496,"links":{},"metadata":{"_buckets":{"deposit":"299c5b88-4ee0-4c42-b3ab-89d1e7c88b91"},"_deposit":{"created_by":17,"id":"2011496","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2011496"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:02011496","sets":["499:508:509:1724896432553"]},"author_link":[],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"463","bibliographicPageStart":"452","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The presence of anti-thyroid antibodies (ATAs) is a biomarker for the development of thyroid dysfunction induced by anti-programmed cell death-1 antibodies (PD-1-Abs). While patients with thyroid dysfunction reportedly showed better overall survival (OS), it remains unknown if ATAs at baseline can predict OS. Therefore, in this study, we examined the association of ATAs at baseline with OS in non-small cell lung cancer (NSCLC) patients with different levels of programmed cell death-1 ligand 1 (PD-L1) positivity associated with PD-1-Ab treatment efficacy. A total of 81 NSCLC patients treated with PD-1-Abs were evaluated for ATAs at baseline and prospectively for OS. Among the 81 patients, 49 and 32 patients had ≥50% (group A) and <50% (group B) PD-L1 positivity, respectively. Median OS did not differ significantly between patients with (n = 13) and without (n = 36) ATAs at baseline in group A. In contrast, median OS was significantly longer in patients with (n = 10) versus without (n = 22) ATAs at baseline in group B (not reached vs 378 days, respectively; 95% CI, 182 to 574 days, p = 0.049). These findings suggest that the presence of ATAs at baseline is a biomarker to predict better treatment efficacy of PD-1-Abs in NSCLC patients with low PD-L1 positivity, while the difference in OS in those with high PD-L1 positivity may be masked by increased tumor expression of PD-L1.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.86.3.452","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/863.html","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_source_id_7":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okuji, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwama, Shintaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Tomoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasuda, Yoshinori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ito, Masaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamagami, Ayana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ando, Masahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hase, Tetsunari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shibata, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hatta, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zhou, Xin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Onoue, Takeshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Yohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyata, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugiyama, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hagiwara, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suga, Hidetaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Banno, Ryoichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ando, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hashimoto, Naozumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arima, Hiroshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-08-29"}],"displaytype":"detail","filename":"09_Okuji.pdf","filesize":[{"value":"785 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/2011496/files/09_Okuji.pdf"},"version_id":"5145c7ed-74de-476a-b060-6b8ae26908d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"autoimmunity","subitem_subject_scheme":"Other"},{"subitem_subject":"lung neoplasms","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarkers","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid","subitem_subject_scheme":"Other"},{"subitem_subject":"programmed cell death-1 (PD-1)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"17","path":["1724896432553"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-29"},"publish_date":"2024-08-29","publish_status":"0","recid":"2011496","relation_version_is_last":true,"title":["Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-09-05T04:59:08.947406+00:00"}