| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-10-16 |
| タイトル |
|
|
タイトル |
A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast |
|
言語 |
en |
| 著者 |
Ohtsuka, Hokuto
Ohara, Kotaro
Shimasaki, Takafumi
Hatta, Yoshiko
Maekawa, Yasukichi
Aiba, Hirofumi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
権利情報 |
"This is the peer reviewed version of the following article: [Ohtsuka, H., Ohara, K., Shimasaki, T., Hatta, Y., Maekawa, Y., & Aiba, H. (2024). A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast. Genes to Cells, 29(8), 667–680. https://doi.org/10.1111/gtc.13136], which has been published in final form at [https://doi.org/10.1111/gtc.13136]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In the fission yeast Schizosaccharomyces pombe, the response to sulfur depletion has been less studied compared to the response to nitrogen depletion. Our study reveals that the fission yeast gene, SPCC417.09c, plays a significant role in the sulfur depletion response. This gene encodes a protein with a Zn2Cys6 fungal-type DNA-binding domain and a transcription factor domain, and we have named it sdr1+ (sulfur depletion response 1). Interestingly, while sulfur depletion typically induces autophagy akin to nitrogen depletion, we found that autophagy was not induced under sulfur depletion in the absence of sdr1+. This suggests that sdr1+ is necessary for the induction of autophagy under conditions of sulfur depletion. Although sdr1+ is not essential for the growth of fission yeast, its overexpression, driven by the nmt1 promoter, inhibits growth. This implies that Sdr1 may possess cell growth-inhibitory capabilities. In addition, our analysis of Δsdr1 cells revealed that sdr1+ also plays a role in regulating the expression of genes associated with the phosphate depletion response. In conclusion, our study introduces Sdr1 as a novel transcription factor that contributes to an appropriate cellular nutrient starvation response. It does so by inhibiting inappropriate cell growth and inducing autophagy in response to sulfur depletion. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/gtc.13136 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1356-9597 |
| 書誌情報 |
en : Genes to Cells
巻 29,
号 8,
p. 667-680,
発行日 2024-08
|
| ファイル公開日 |
|
|
日付 |
2025-08-01 |
|
日付タイプ |
Available |
Sdr1_Genes_to_Cells.pdf (2.1 MB)
