| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-01-21 |
| タイトル |
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|
タイトル |
The role of circadian clock gene Arntl in the winter depression-like behavior in melatonin-proficient female CBA/N mice |
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言語 |
en |
| 著者 |
Ren, Liang
Okimura, Kousuke
Ishikawa, Akira
Kon, Naohiro
Shimba, Shigeki
Yoshimura, Takashi
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Seasonal affective disorder (SAD), also known as winter depression, is a subtype of depression typically manifesting in winter. Typical symptoms of SAD, such as an increased need for sleep and carbohydrate cravings associated with increased appetite and weight, are distinct from those of major depression, and the underlying mechanisms of SAD remain unclear. Although laboratory mice are generally considered non-seasonal animals, we observed depression-like behaviors in melatonin-proficient female CBA/N mice maintained under winter-mimicking conditions. Transcriptome analysis of the brains of CBA/N mice maintained under winter- and summer-mimicking conditions revealed changes in the expression of circadian clock genes, including Arntl (also known as Bmal1). We generated Arntl-deficient, melatonin-proficient CBA/N mice using the speed congenic method to examine the role of Arntl in depressive behavior. The tail suspension test in these mice revealed a depressive phenotype. These results suggested that the circadian clock gene Arntl may be involved in winter depression-like behavior. |
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言語 |
en |
| 出版者 |
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出版者 |
Elsevier |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2024.150790 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0006291X |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 734,
p. 150790,
発行日 2024-11-19
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| ファイル公開日 |
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|
日付 |
2025-11-19 |
|
日付タイプ |
Available |
Ren_BBRC_repository.pdf (998 KB)
