| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-03-04 |
| タイトル |
|
|
タイトル |
Mismatch repair deficiency and its relationship with histopathological features in gastric cancer patients |
|
言語 |
en |
| 著者 |
Nguyen, Thi Hong Chuyen
Nguyen, Tran Bao Song
Nguyen, Thanh Phuc
Ha, Thi Minh Thi
Pham, Nguyen Cuong
Nguyen, Thi Thu Giang
Phan, Minh Tri
Le, Thanh Huy
Ha, Thanh Thanh
Nguyen, Tran Thuc Huan
Dang, Cong Thuan
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
gastric cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
microsatellite instability |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
mismatch repair deficiency |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
histopathological features |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
immunohistochemical |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Gastric cancer is a common malignancy disease with a poor prognosis. Deficient mismatch repair is a prognostic and predictive marker of response to systemic therapies. However, deficient mismatch repair frequency and the relationship between this status and microscopic characteristics are inconsistent across nations. We aimed to determine the rate of deficient mismatch repair and its association with histopathological features in gastric cancer patients. A cross-sectional study was conducted on 226 gastric cancer patients treated at Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital from June 2020 to January 2024. Mismatch repair protein expression was evaluated using immunohistochemical staining, and any absence of mismatch repair proteins was regarded as deficient mismatch repair. The deficient mismatch repair rate was 12.8%. Deficient mismatch repair appeared to be more frequent in the intestinal subtype of Lauren classification odds ratio (OR) = 4.767 (95% confidence interval [CI], 1.086–20.921; p = 0.039), tubular/papillary adenocarcinoma (OR = 5.25; 95% CI, 1.185–23.251; p = 0.029), mucinous adenocarcinoma (OR = 6.19; 95% CI, 1.113–34.445; p = 0.037), and differentiated type (OR = 3.24; 95% CI, 1.324–7.931; p = 0.01). No statistically significant association was detected with histopathological features according to the Tumor Location-Modified Lauren classification and mucinous secreting morphology. Deficient mismatch repair status was unusual in gastric cancer. The degree of cell differentiation and microscopic characteristics based on the World Health Organization and Lauren classification could all impact the predictive power for microsatellite-instable status. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.87.1.93 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/871.html |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 87,
号 1,
p. 93-104,
発行日 2025-02
|
08_Nguyen.pdf (2.3 MB)
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