| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-05-15 |
| タイトル |
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タイトル |
Modulable Supramolecular Hydrogels via Co-Assembly Using Cyclic Dipeptides: Influence of One Methyl Group |
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言語 |
en |
| 著者 |
Shintani, Yuki
Higashi, Sayuri L.
Shibata, Aya
Hirosawa, Koichiro M.
Suzuki, Kenichi G. N.
Kawano, Shin-ichiro
Katagiri, Hiroshi
Ikeda, Masato
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in [Chemistry of Materials], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-QZYYFBAGMYA3Y3RGCDFZ].” |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Self-assembling peptide derivatives containing unnatural amino acids are promising for the modulation of the structure and function of supramolecular architectures consisting of natural peptide-based derivatives through co-assembly. In this study, we investigate the self-assembly of three cyclic dipeptides that contain synthetic α-methyl-l-phenylalanine as the unnatural amino acid in an aqueous medium. We reveal that one of the three synthesized cyclic dipeptides can form a supramolecular hydrogel and resolve the self-assembled architecture and the folded conformation at the atomic scale, where one methyl group introduced at the α-carbon of l-phenylalanine significantly influenced the properties of the hydrogel. Furthermore, we demonstrate that co-assembly with its natural counterpart enables modulation of the viscoelastic properties of supramolecular hydrogels. Thus, our study may facilitate the exploration of unnatural peptide-based self-assembling molecular libraries for the construction of supramolecular soft materials. |
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言語 |
en |
| 出版者 |
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出版者 |
ACS Publications |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1021/acs.chemmater.4c03245 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0897-4756 |
| 書誌情報 |
en : Chemistry of Materials
巻 37,
号 6,
p. 2241-2250,
発行日 2025-03-25
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| ファイル公開日 |
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日付 |
2026-03-25 |
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日付タイプ |
Available |
Manuscript.pdf (2.6 MB)
