| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-05-27 |
| タイトル |
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|
タイトル |
Meflin/Islr is a marker of fibroblasts that arise in fibrotic regions after spinal cord injury |
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言語 |
en |
| 著者 |
Morita, Yoshinori
Shiraki, Yukihiro
Kato, Akira
Nagatani, Yasuhiro
Ando, Ryota
Nakashima, Hiroaki
Imagama, Shiro
Enomoto, Atsushi
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
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主題Scheme |
Other |
|
主題 |
spinal cord injury |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
fibrosis |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Meflin |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
immunoglobulin superfamily containing leucine rich |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Scar formation after spinal cord injury (SCI) hampers axonal regeneration and functional recovery. Previous studies have shown that scar formation is attributable to both gliosis and fibrosis, the latter requiring fibroblast proliferation and extracellular matrix deposition. In this setting, there are essentially two cell types generating new fibroblasts: pericytes and tissue-resident fibroblasts. Here, we showed that Meflin, a glycosylphosphatidylinositol-anchored protein (a specific marker of fibroblasts across multiple organs) is expressed by fibroblasts in the normal mouse spinal cord. An in situ hybridization analysis showed that Meflin+ cells arose from the meninges and perivascular region of the spinal parenchyma after spinal cord compression injury. That finding was corroborated by single-cell transcriptomic data from normal and injured mouse spinal cords. Interestingly, Meflin+ cells are positive for the fibroblast markers collagen type I and platelet-derived growth factor receptor (PDGFR) α but not for pericyte markers such as PDGFRβ and chondroitin sulfate proteoglycan 4 in the normal spinal cord. Those findings are consistent with the recent view that tissue-resident fibroblasts play a central role in many other types of fibrotic disease. A lineage-tracing experiment using a knock-in mouse line that expressed inducible Cre recombinase under the control of the Meflin promoter showed that Meflin+ cells yield PDGFRβ+ myofibroblasts but not glial cells positive for glial fibrillary acidic protein. These findings suggest that the Meflin+ population contains the cells of origin of myofibroblasts that are involved in scar formation after SCI. |
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言語 |
en |
| 出版者 |
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出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.87.2.305 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/872.html |
| 助成情報 |
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|
識別子タイプ |
Crossref Funder |
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|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
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助成機関名 |
日本学術振興会 |
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|
言語 |
ja |
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助成機関名 |
Japan Society for the Promotion of Science |
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言語 |
en |
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研究課題番号 |
22H02848 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24110/ |
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研究課題名 |
線維芽細胞の形質維持不全と老化が個体の生理機能と病態に与える影響の解明 |
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言語 |
ja |
| 助成情報 |
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|
識別子タイプ |
Crossref Funder |
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|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
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|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
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研究課題番号 |
22K18390 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K18390/ |
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研究課題名 |
間葉系幹細胞/血管周囲線維芽細胞の未分化性誘導法の開発と線維化疾患への応用 |
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言語 |
ja |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0027-7622 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 87,
号 2,
p. 305-319,
発行日 2025-05
|
11_Morita.pdf (11.2 MB)
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