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Molecular Design of Dual Redox-Active Phospholipid Polymers with a Potent Anticancer Activity
http://hdl.handle.net/2237/0002012793
http://hdl.handle.net/2237/00020127934c6f6d93-04f1-47b0-8ca0-3af8b33b6a3d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Ogawa_Dualredox_manuscript_R2_clean.pdf (1.4 MB)
Download is available from 2026/4/25.
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| アイテムタイプ | itemtype_ver1(1) | |||||||||||
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| 公開日 | 2025-05-28 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Molecular Design of Dual Redox-Active Phospholipid Polymers with a Potent Anticancer Activity | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
Ogawa, Yuki
× Ogawa, Yuki
× Kaneko, Masahiro
× Ito, Akira
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| アクセス権 | ||||||||||||
| アクセス権 | embargoed access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | "This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ACS Applied Polymer Materials], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-5XTT43WA6PSNKAU5TT3I].” | |||||||||||
| 言語 | en | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Redox-active compounds that disrupt the intracellular redox balance are promising anticancer agents because of the vulnerability of cancer cells to oxidative stress. The conjugation of different redox-active molecules can effectively achieve high therapeutic efficacy but can also lead to challenges owing to their typically poor water solubility and complicated organic synthesis. In this study, we designed a water-soluble, cell-penetrating, dual redox-active polymer (pMBFcAq) containing ferrocene (Fc) and anthraquinone (Aq) units. pMBFcAq retained the redox activity originating from the Fc and Aq units and induced oxidative stress and cell death more strongly against mouse colon cancer CT26 cells than polymers containing either Aq or Fc units alone. The in vitro anticancer activity of pMBFcAq was enhanced by adjusting its composition. Moreover, pMBFcAq significantly suppressed the in vivo growth of CT26 tumors, indicating potent anticancer activity. This study provides a strategy for the development of redox-active polymers with high therapeutic efficacy. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | ACS Publications | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| 関連情報 | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1021/acsapm.5c00350 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2637-6105 | |||||||||||
| 書誌情報 |
en : ACS Applied Polymer Materials 巻 7, 号 8, p. 5070-5076, 発行日 2025-04-25 |
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| ファイル公開日 | ||||||||||||
| 日付 | 2026-04-25 | |||||||||||
| 日付タイプ | Available | |||||||||||
