| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-06-12 |
| タイトル |
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タイトル |
Cobalt-Catalyzed Enantioselective Desymmetrization and Chemodivergent Parallel Kinetic Resolution of Unsaturated Substrates via C(sp3)–H Bond Activation |
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言語 |
en |
| 著者 |
Yamada, Keiji
Hashiyama, Ryo
Yasui, Takeshi
Yamamoto, Yoshihiko
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ACS Catalysis], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-EVBQRFI7BEI7Y3YHMBZX].” |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
In transition-metal-mediated chemical transformations, chemoselective or chemodivergent activation of inert C–H bonds in the presence of more reactive alkene or alkyne π-bonds is a fundamental challenge. Herein, we report the Co-catalyzed cycloisomerization of unsaturated substrates bearing a 1,6-diyne moiety via enantioselective desymmetrization and parallel kinetic resolution involving the chemoselective and chemodivergent activation of a C(sp3)–H bond. The enantioselective desymmetrization of symmetrical dienediynes was demonstrated using a 1,1′-binaphthyl-based chiral phosphine ligand to afford the corresponding enantioenriched 1,3-diene products. The parallel kinetic resolution of unsymmetrical substrates such as enetriynes, dienediynes, and diynenitriles was also demonstrated, where the chemodivergent activation of a C(sp3)–H bond and an alkene, alkyne, or nitrile π-bond was achieved. The 1,3-diene products were successfully derivatized to 5–8–5 tricyclic compounds via a central-to-helical-to-central chirality transfer involving memory of chirality. |
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言語 |
en |
| 出版者 |
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出版者 |
ACS Publications |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1021/acscatal.5c00132 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2155-5435 |
| 書誌情報 |
en : ACS Catalysis
巻 15,
号 5,
p. 3860-3872,
発行日 2025-03-07
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| ファイル公開日 |
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|
日付 |
2026-03-07 |
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日付タイプ |
Available |
2.pdf (1.9 MB)
