| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-06-30 |
| タイトル |
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タイトル |
Underlying Disorders in Children With Infection-Related Acute Encephalopathy. |
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言語 |
en |
| 著者 |
Nakata, Tomohiko
Natsume, Jun
Yamamoto, Hiroyuki
Ito, Yuji
Suzuki, Takeshi
Kawaguchi, Masahiro
Shiraki, Anna
Kumai, Sumire
Sawamura, Fumi
Suzui, Ryosuke
Mitsumatsu, Takamasa
Narita, Hajime
Tsuji, Takeshi
Kubota, Tetsuo
Saitoh, Shinji
Okumura, Akihisa
Kidokoro, Hiroyuki
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Various factors contribute to the development of infection-related acute encephalopathy (AE) in children, such as infectious agents and chronic underlying disorders. We studied underlying disorders in children with AE to identify predisposing factors of AE. Methods: We investigated underlying disorders or past histories in patients with two types of AE from the database in the Tokai area of Japan between 2009 and 2022: 204 patients with AE with reduced subcortical diffusion (AED) and 137 with clinically mild encephalopathy with a reversible splenial lesion (MERS). We compared them with 89 patients with acute disseminated encephalomyelitis (ADEM) to clarify the specific disorders in the two AE types. Results: The prevalence of underlying disorders in AED (34%, 70 patients) was significantly higher than that in ADEM (12%, 11 patients) (P < 0.01). The prevalence of underlying disorders in MERS was 23% (32 patients). The underlying disorders included seizure disorders, premature birth, genetic/congenital disorders, and endocrine/renal diseases. In patients with seizure disorders in AED, five patients (18%) had Dravet syndrome and four (15%) had West syndrome, whereas none with MERS had these syndromes. Twenty-five (12%) of 204 patients with AED, three (2%) with MERS, and one (1%) with ADEM were preterm or low birth weight. Conclusion: The high prevalence of seizure disorders suggests that seizure susceptibility is an important predisposing factor in AED. Premature birth also has an impact on the development of AED. Caution is required regarding the development of AE in patients with chronic seizure disorders or premature birth. |
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言語 |
en |
| 出版者 |
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出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.pediatrneurol.2024.03.017 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0887-8994 |
| 書誌情報 |
en : Pediatric neurology
巻 155,
p. 126-132,
発行日 2024-06
|
Manuscript_PedNeuro_Undelying_disorders_in_AE_final_revise.pdf (745 KB)
