| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-09-09 |
| タイトル |
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|
タイトル |
Calcium chloride within carbon dioxide absorbents prevents Compound A production from sevoflurane |
|
言語 |
en |
| 著者 |
Ando, Takahiro
Mori, Atsushi
Nakatochi, Masahiro
Nishiwaki, Kimitoshi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
calcium chloride |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
carbon dioxide absorbents |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Compound A |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
deliquescent |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
sevoflurane |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Calcium chloride (CaCl2)-containing carbon dioxide (CO2) absorbers are characterized by their ability to produce almost no pentafluoroisopropenyl fluoromethyl ether (Compound A), a potentially nephrotoxic byproduct of sevoflurane, in vitro. However, the precise role of CaCl2 in this process remains unclear. We aimed to clarify the role of CaCl2 in vitro and determine whether CaCl2-containing CO2 absorbents produce Compound A during prolonged surgery under low- and minimal-flow sevoflurane anesthesia using Japanese brand Yabashi Lime-f (YL-f). In vitro, a reaction between 1 L of sevoflurane gas (8%) with 5% CO2 and an absorbent specimen (20 g) with or without water was performed in an artificial closed-circuit system for 15 or 60 min at 45 °C. In vivo, patients scheduled for colorectal resection received 2.0 vol% sevoflurane at fresh gas flows of 2.0, 1.0, or 0.5 L/min (N = 6) with YL-f. Gas samples from the anesthetic circuit were collected 6 h after induction and at the conclusion of surgeries lasting over 7 h. Compound A concentrations were measured using gas chromatography-flame ionization detection. Compound A production was observed in CaCl2-free absorbents but not in those containing CaCl2 in vitro. During 60-min reactions, CaCl2-free YL-f derivatives produced a median 3.5 ppm of Compound A, with higher concentrations (7.1 ppm) observed upon the addition of 3 mL of water. YL-f did not produce Compound A, regardless of the presence of water. Compound A was not detected in in vivo samples. In conclusion, CaCl2 suppresses Compound A production from sevoflurane, likely by trapping water within the anesthetic circuit. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.87.3.392 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/873.html |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 87,
号 3,
p. 392-406,
発行日 2025-08
|
02_Ando.pdf (5.1 MB)
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