| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-09-09 |
| タイトル |
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|
タイトル |
Comparative analysis of bone regeneration in critical-sized defects using self-assembling peptide hydrogel-178, bone morphogenetic protein-2, and calcium phosphate scaffolds in a rat femur model |
|
言語 |
en |
| 著者 |
Yamauchi, Ippei
Nakashima, Hiroaki
Ito, Sadayuki
Segi, Naoki
Ouchida, Jun
Morita, Yoshinori
Ode, Yukihito
Nagatani, Yasuhiro
Okada, Yuya
Ando, Kei
Imagama, Shiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
bone regeneration |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
self-assembling peptide hydrogel |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
BMP-2 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hydroxyapatite |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
β-tricalcium phosphate |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Bone regeneration is a highly demanded but challenging clinical endeavor in orthopedic surgery, necessitating the development of alternative bone grafting materials. This study aimed to evaluate the bone regenerative potential of self-assembling peptide hydrogel (0.8%), bone morphogenetic protein-2 (50 ng/μL), hydroxyapatite, and b-tricalcium phosphate, both individually and in combination with bone chips, in a rat femoral defect model. Ten-week-old female Wistar rats underwent surgical implantation of a polyetheretherketone cage into a 5-mm bony defect within the left femoral mid-shaft, maintained by an external fixator. Polyetheretherketone cages were filled with bone substitute materials alone in the first experiment and with bone substitute materials combined with bone chips in the second experiment. Radiographic and histological analyses were conducted following sacrifice at 56 weeks. While selfassembling peptide hydrogel alone exhibited moderate bone formation, with a bone-volume-to-total-volume ratio of 0.34 ± 0.09, this value was not significantly higher than that of the control group with an empty polyetheretherketone cage. Conversely, the combination of bone morphogenetic protein-2 with bone chips produced the highest level of bone regeneration, with a bone-volume-to-total-volume ratio of 0.78 ± 0.05, significantly surpassing bone chips alone (p < 0.01) and self-assembling peptide hydrogel with bone chips (p < 0.05). These findings suggest that while self-assembling peptide hydrogel holds potential as a scaffold material, particularly in minimally invasive applications, its efficacy in promoting robust bone regeneration may benefit from the inclusion of osteoinductive factors, such as bone morphogenetic protein-2. |
|
言語 |
en |
| 出版者 |
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出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
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|
ID登録 |
10.18999/nagjms.87.3.421 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/873.html |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0027-7622 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 87,
号 3,
p. 421-430,
発行日 2025-08
|
04_Yamauchi.pdf (27.3 MB)
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