| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2024-09-09 |
| タイトル |
|
|
タイトル |
A case of primary cutaneous diffuse large B-cell lymphoma, leg type with MYC rearrangement and high BCL2 protein expression due to trisomy 18 |
|
言語 |
en |
| 著者 |
Matsui, Yosuke
Katsumi, Akira
Tanaka, Ken
Ohara, Fumiya
Motegi, Kenta
Abe, Akihiro
Tamura, Shogo
Yamamoto, Katsuya
Matsushita, Tadashi
Adachi, Miwa
Nagata, Yasuyuki
Hasegawa, Masaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
primary cutaneous diffuse large B-cell lymphoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
leg type |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
trisomy 18 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
high BCL2 expression |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
double-expressor lymphoma |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We report the case of an 80-year-old woman with a medial thigh nodule who was diagnosed with primary cutaneous diffuse large B-cell lymphoma, leg type. Further examination identified it as doubleexpressor lymphoma with elevated expression of both MYC and BCL2. This elevated expression has been linked to MYC translocation and is likely associated with trisomy 18. Our findings suggest that trisomy 18 plays a significant role in the development of double-expressor lymphoma. While cases of doubleexpressor lymphoma caused by extra copies of BCL2 have been reported, we could not find any case of double-expressor lymphoma caused by trisomy 18. Therefore, this is an unique case of double-expressor lymphoma linked to MYC rearrangement and trisomy 18. Double-expressor lymphoma typically has a poor prognosis and is often resistant to standard treatments. The current findings may help refine diagnostic strategies for this condition. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.87.3.582 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/873.html |
| 助成情報 |
|
|
|
識別子タイプ |
Crossref Funder |
|
|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
|
|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題番号 |
22K08518 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08518/ |
|
|
研究課題名 |
血小板におけるRhoA-フォルミンを介した新規脂質シグナル調節機構の解明 |
|
|
言語 |
ja |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 87,
号 3,
p. 582-589,
発行日 2025-08
|
18_Matsui.pdf (10.4 MB)
.png)
