| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-08-28 |
| タイトル |
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タイトル |
Characterization of P-type H+-ATPase Pma1 inhibitors that extend chronological lifespan in fission yeast |
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言語 |
en |
| 著者 |
Tamura, Masahiro
Yamashita, Wakana
Hibi, Takahide
Inui, Shougo
Tanaka, Koki
Ozako, Mami
Shimasaki, Takafumi
Ohtsuka, Hokuto
Shibuya, Masatoshi
Yamamoto, Yoshihiko
Yokoshima, Satoshi
Aiba, Hirofumi
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| アクセス権 |
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アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00438-025-02264-4. |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
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内容記述 |
Inhibition of the activity of Pma1, a widely conserved P-type proton exporting ATPase, has been shown to extend the chronological lifespan (CLS) in fission yeast Schizosaccharomyces pombe. To develop a specific inhibitor for Pma1 of S. pombe, we focused on Si01, a candidate inhibitor of Saccharomyces cerevisiae Pma1. First, we have established a method for synthesis of Si01 and then investigated its Pma1 inhibitory activity and lifespan extension effect in fission yeast. Second, we also synthesized derivatives of Si01 and determined the minimum structure required for inhibition of S. pombe Pma1. Here we showed that the inhibitory activity of Pma1 correlates with the effect of lifespan extension. Si01 reduced the activity of purified Pma1 protein and extended the CLS of not only fission yeast but also budding yeast. These results provide a molecular basis for understanding the mechanism of Pma1 inhibition and the potential for developing molecules that regulate lifespan. |
|
言語 |
en |
| 出版者 |
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出版者 |
Springer |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1007/s00438-025-02264-4 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1617-4615 |
| 書誌情報 |
en : Molecular Genetics and Genomics
巻 300,
p. 58,
発行日 2025-06-08
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| ファイル公開日 |
|
|
日付 |
2026-06-08 |
|
日付タイプ |
Available |
Molecular_Genetics_and_Genomics_300_2025_58.pdf (1.5 MB)
