| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-10-07 |
| タイトル |
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|
タイトル |
All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma |
|
言語 |
en |
| 著者 |
Kaneko, Masahiro
Saito, Rintaro
Nishikawa, Ami
Ito, Akira
|
| アクセス権 |
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|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
"This is the peer reviewed version of the following article: [M. Kaneko, R. Saito, A. Nishikawa, A. Ito, All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma. Adv. Healthcare Mater. 2025, 14, 2500260. https://doi.org/10.1002/adhm.202500260], which has been published in final form at [https://doi.org/10.1002/adhm.202500260]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Hyperthermia using magnetic nanoparticles is a promising cancer therapy that locally destroys tumors and induces antitumor immunity by releasing tumor antigens from dying cells. However, magnetic hyperthermia in malignant melanomas with poor immunogenicity and an immunosuppressive microenvironment remains challenging. Here, all-in-one magnetic nanoparticles (αPD-L1/CpG@MCL) are developed for thermo-immunotherapy that enables hyperthermia with magnetic nanoparticles and immunotherapy with anti-PD-L1 antibody and CpG to improve the immunosuppressive tumor microenvironment. Magnetic hyperthermia with magnetite cationic liposomes (MCL, without anti-PD-L1 antibody and CpG) inhibits tumor growth in B16F10 melanoma; however, complete tumor regression is not observed. In contrast, complete tumor regression is observed when mice are treated with thermo-immunotherapy using αPD-L1/CpG@MCL. Additionally, mice cured after magnetic hyperthermia with αPD-L1/CpG@MCL rejected rechallenge with B16F10 cells, and cytotoxicity assay using splenocytes from cured mice shows the induction of antitumor immunity against B16F10 cells. Analysis of tumor-infiltrating lymphocytes reveals that magnetic hyperthermia with αPD-L1/CpG@MCL increased CD8+ T lymphocytes and M1-like macrophages, and decreased M2-like macrophages, indicating an improvement in the tumor microenvironment. This study provides a key design strategy for all-in-one magnetic nanoparticles that could cure malignant melanomas. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/adhm.202500260 |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
2192-2640 |
| 書誌情報 |
en : Advanced Healthcare Materials
巻 14,
号 20,
p. 2500260,
発行日 2025-08-08
|
| ファイル公開日 |
|
|
日付 |
2026-08-08 |
|
日付タイプ |
Available |
AllInOne_Manuscript_AHM_revised_for submission_clean.pdf (1.5 MB)
