| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-10-08 |
| タイトル |
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|
タイトル |
Determinants of clinical and neurophysiological features in essential tremor and essential tremor plus |
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言語 |
en |
| 著者 |
Tsuboi, Takashi
Uematsu, Takashi
Sawada, Keito
Higuchi, Moeka
Hashida, Miki
Muto, Manabu
Ito, Yoshiki
Ishizaki, Tomotaka
Kato, Sachiko
Nakatsubo, Daisuke
Tsugawa, Takahiko
Maesawa, Satoshi
Saito, Yuki
Fukushima, Taiki
Tamakoshi, Daigo
Hiraga, Keita
Suzuki, Masashi
Saito, Ryuta
Ramirez-Zamora, Adolfo
Okun, Michael S.
Katsuno, Masahisa
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| アクセス権 |
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|
アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00702-025-02941-z |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
The 2018 Movement Disorder Society classification introduced essential tremor plus (ETP) as a category for patients with essential tremor (ET) accompanied by additional features of uncertain significance. While earlier studies have characterized clinical features of ETP, the factors that characterize the phenotypic expression of ETP remain unclear. We prospectively evaluated 70 consecutive patients with ET or ETP. Clinical and neurophysiological assessments included tremor severity (Clinical Rating Scale for Tremor, CRST), cognitive functions (Addenbrooke’s Cognitive Examination Revised, ACE-R), and accelerometric analysis. Statistical analyses examined between-group differences and factors influencing tremor characteristics. The prevalence of ETP (61%) exceeded that of ET. Among ETP patients, 77% exhibited two or more additional motor and/or cognitive features. Compared to ET patients, ETP patients demonstrated significantly higher tremor severity, lower tremor frequency, older age at assessment and onset, and poorer cognitive function, despite comparable disease duration. The accelerometric analysis revealed similar tremor patterns in both groups with quantitative differences in tremor amplitude and frequency. The propensity score matching and multiple regression analyses suggested that tremor severity and frequency are more influenced by age than by disease duration or diagnostic classification of ET/ETP. ACE-R score and the presence of resting tremor were also significant predictors of tremor severity. ETP represents a heterogeneous population with diverse neurological features, and age is likely a key determinant of severity and phenotypic expression. Comprehensive analysis is needed to identify other factors that may determine phenotype and treatment responsiveness. |
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言語 |
en |
| 出版者 |
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出版者 |
Springer |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1007/s00702-025-02941-z |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0300-9564 |
| 書誌情報 |
en : JOURNAL OF NEURAL TRANSMISSION
巻 132,
号 7,
p. 1041-1050,
発行日 2025-07
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| ファイル公開日 |
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|
日付 |
2026-07-01 |
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日付タイプ |
Available |
ETvsETP_20250424.pdf (449 KB)
