| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-10-31 |
| タイトル |
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タイトル |
Reticulon 4 reflects endoplasmic reticulum stress in arginine vasopressin neurons |
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言語 |
en |
| 著者 |
Kawaguchi, Yohei
Hodai, Yuichi
Naito, Satoshi
Kondo, Yuichi
Tsumura, Tetsuro
Miyata, Takashi
Kobayashi, Tomoko
Sugiyama, Mariko
Onoue, Takeshi
Iwama, Shintaro
Suga, Hidetaka
Banno, Ryoichi
Arima, Hiroshi
Hagiwara, Daisuke
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| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
"This is a non-final version of an article published in final form in (Kawaguchi, Yohei; Hodai, Yuichi; Naito, Satoshi; Kondo, Yuichi; Tsumura, Tetsuro; Miyata, Takashi; Kobayashi, Tomoko; Sugiyama, Mariko; Onoue, Takeshi; Iwama, Shintaro; Suga, Hidetaka; Banno, Ryoichi; Arima, Hiroshi; Hagiwara, Daisuke. Reticulon 4 reflects endoplasmic reticulum stress in arginine vasopressin neurons. NeuroReport 36(10):p 540-546, July 02, 2025. | DOI: 10.1097/WNR.0000000000002174)." |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objectives: Arginine vasopressin (AVP) is synthesized in the magnocellular supraoptic nucleus and paraventricular nuclei of the hypothalamus, where AVP neurons function under a consistently high demand for AVP production. AVP neurons are subject to endoplasmic reticulum (ER) stress even under basal conditions, and this ER stress is further exacerbated when AVP production increases due to dehydration. Reticulon (RTN) is essential for ER formation and stabilization and plays a critical role in membrane morphogenesis within the ER. This study aimed to investigate the expression of RTN family members in hypothalamic AVP neurons. Methods: Fluorescence immunohistochemistry and in-situ hybridization were employed to examine the expression of RTN family members in hypothalamic AVP neurons of adult male mice. Water deprivation and treatment with a chemical chaperone 4-phenylbutyric acid were used to increase and decrease the ER stress of AVP neurons, respectively. Results: Among the RTN family members, only RTN4 was found to be expressed in hypothalamic AVP neurons. RTN4 was colocalized with ER organelle markers, including immunoglobulin heavy chain binding protein and calnexin. Furthermore, RTN4 expression increased during ER stress induced by water deprivation. On the other hand, increased RTN4 expression by water deprivation was attenuated by 4-phenylbutyric acid treatment. Conclusions: Our results suggest that RTN4 expression in AVP neurons is closely associated with ER stress caused by increased protein production in neuroendocrine cells. |
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言語 |
en |
| 出版者 |
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出版者 |
Wolters Kluwer Health |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1097/WNR.0000000000002174 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0959-4965 |
| 書誌情報 |
en : NeuroReport
巻 36,
号 10,
p. 540-546,
発行日 2025-07-02
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| ファイル公開日 |
|
|
日付 |
2026-07-02 |
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日付タイプ |
Available |
RTN4_manuscript_25-01-11.pdf (1.7 MB)
