| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-11-26 |
| タイトル |
|
|
タイトル |
Expanding the therapeutic horizon of 177Lu-DOTATATE: a review of current evidence |
|
言語 |
en |
| 著者 |
Minamimoto, Ryogo
Kato, Katsuhiko
Iwano, Shingo
Nishii, Ryuichi
Abe, Yumi
Naganawa, Shinji
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neuroendocrine tumors (NETs) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
somatostatin receptors (SSTRs) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
peptide receptor radionuclide therapy (PRRT) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
177Lu-DOTATATE |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
gastroenteropancreatic NETs (GEP-NETs) |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Neuroendocrine tumors (NETs) are a heterogenous group of neoplasms originating from neuroendocrine cells, most frequently found in the gastrointestinal tract and pancreas. A defining feature of NETs is the overexpression of somatostatin receptors (SSTRs), particularly subtype 2 (SSTR2), which is the primary target for both diagnostic imaging and therapeutic interventions. Peptide receptor radionuclide therapy (PRRT) using 177Lu-DOTATATE, a radiolabeled somatostatin analog, has emerged as a transformative alternative for patients with advanced or progressive well-differentiated NETs. Considering that SSTR expression is also present in various other tumors—including pheochromocytomas, paragangliomas, meningiomas, and medullary thyroid carcinomas—there is increasing interest in expanding the use of PRRT to other SSTR-positive malignancies. This review aimed to present evidence, explore ongoing clinical research, and highlight emerging directions for 177Lu-DOTATATE therapy beyond gastroenteropancreatic NETs. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.87.4.607 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/874.html |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 87,
号 4,
p. 607-631,
発行日 2025-11
|
02_Minamimoto.pdf (1.7 MB)
.png)
