| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-12-01 |
| タイトル |
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タイトル |
Regiodivergent Photocatalytic Annulation for the Synthesis of gem-Difluorinated Cyclic Hydrocarbons |
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言語 |
en |
| 著者 |
Schirmer, Tobias E.
Kürschner, Julian C. G.
Uchida, Yuki
Taura, Yuya
Gabriel, Pablo
Næsborg, Line
Yokogawa, Daisuke
Aramaki, Yoshitaka
Ooi, Takashi
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| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
"This is the peer reviewed version of the following article: [T. E. Schirmer, J. C. G. Kürschner, Y. Uchida, Y. Taura, P. Gabriel, L. Næsborg, D. Yokogawa, Y. Aramaki, T. Ooi, Angew. Chem. Int. Ed. 2025, 64, e202502450. https://doi.org/10.1002/anie.202502450], which has been published in final form at [https://doi.org/10.1002/anie.202502450]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
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内容記述 |
Regiodivergent synthesis is a powerful strategy for expanding chemical space. Given the significance of fluorine-containing molecules in pharmaceutical sciences, a regiodivergent [3+2] cycloaddition of gem-difluorocyclopropyl urea to olefins and [1.1.0]-bicyclobutanes was developed by employing cationic iridium complexes as photocatalysts under visible-light irradiation. By properly selecting a counteranion of the photocatalyst and tuning the reaction conditions, each regioisomeric cyclic hydrocarbon with a defined gem-difluoromethylene disposition was directly assembled with high selectivity. Mechanistic elucidation revealed the critical relevance of the basicity of the photocatalyst counteranion to the regiochemical outcome. The reaction diverges depending on the intervention of deprotonation of the initially generated urea radical cation by the pairing anion to form the corresponding neutral radical; this not only governs the regioselective ring opening of the cyclopropane moiety but also modulates the relative reactivity of the two resulting terminal carbon radicals, thereby dictating the dominant pathway. |
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言語 |
en |
| 出版者 |
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出版者 |
Wiley |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/anie.202502450 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1433-7851 |
| 書誌情報 |
en : ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
巻 64,
号 34,
p. e202502450,
発行日 2025-08-18
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| ファイル公開日 |
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|
日付 |
2026-08-18 |
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日付タイプ |
Available |
manuscript.pdf (1.6 MB)
