| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-12-04 |
| タイトル |
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|
タイトル |
Simple and early prediction of severe CAR-T-related adverse events after Axi-cel infusion by initial high fever |
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言語 |
en |
| 著者 |
Wakabayashi, Hiroya
Terakura, Seitaro
Ishigiwa, Kohei
Ohara, Fumiya
Hirano, Shiho
Yokota, Hirofumi
Kuwano, Shihomi
Furukawa, Katsuya
Shimada, Kazuyuki
Sato, Takahiko
Hanajiri, Ryo
Kiyoi, Hitoshi
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| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12185-025-03957-7 |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
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内容記述 |
Chimeric antigen receptor T-cell (CAR-T)-related adverse events (CAR-AEs), such as immune effector cell-associated neurotoxicity syndrome (ICANS) and cytokine release syndrome (CRS), can be life-threatening and may require high-dose steroids. Identifying patients at high risk for severe CAR-AEs in a simplified way is crucial for early therapeutic intervention. This retrospective study analyzed 44 patients treated with axicabtagene ciloleucel (Axi-cel) to identify predictive factors for severe CAR-AEs. We found that grade ≥ 3 ICANS, hemophagocytic syndrome, and ICU admission were associated with a greater need for high-dose steroids, which we defined as events associated with high-dose steroids (EHS). The incidence of EHS was significantly higher in patients who developed an initial fever (≥ 38.6 °C) within 24 h of CAR-T infusion (p < 0.001). Progression-free survival (PFS) was significantly shorter in patients with EHS compared to those without EHS (p < 0.001). Additionally, patients who developed a fever within 24 h and those with a peak fever of ≥ 38.6 °C both tended to have higher peak CAR-T counts compared to other patients. Our findings suggest that an initial fever (≥ 38.6 °C) within 24 h of Axi-cel infusion may predict severe CAR-AEs requiring high-dose steroids, and that EHS is associated with worse PFS. |
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言語 |
en |
| 出版者 |
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出版者 |
Springer |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s12185-025-03957-7 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0925-5710 |
| 書誌情報 |
en : INTERNATIONAL JOURNAL OF HEMATOLOGY
巻 122,
号 1,
p. 106-116,
発行日 2025-07
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| ファイル公開日 |
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|
日付 |
2026-07-01 |
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日付タイプ |
Available |
IJHM-D-24-00587_R2.pdf (1000 KB)
