| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2025-12-19 |
| タイトル |
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タイトル |
Colloidal Synthesis of Ag2MnSnS4 Quantum Dots for Bioimaging Applications |
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言語 |
en |
| 著者 |
Jiang, Chang
Akiyoshi, Kazutaka
Kameyama, Tatsuya
Kumagai, Jun
Yamamoto, Takahisa
Yamamoto, Masahiro
Yamada, Shota
Banno, Naoki
Saito, Yutaro
Sumiyoshi, Akira
Wake, Hiroaki
Yukawa, Hiroshi
Baba, Yoshinobu
Torimoto, Tsukasa
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| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ACS Applied Nano Materials], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-76Y4KREENFV4F2JKRDQT].” |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Ag2MnSnS4 (AMTS), a member of the multinary I2–II–IV–VI4 compound family, exhibits a high absorption coefficient and intrinsic magnetic properties. While bulk AMTS crystals were synthesized via high-temperature solid-state methods, reports of AMTS quantum dots (QDs) remained scarce. Here, we report the first colloidal synthesis of AMTS QDs by optimizing reaction temperature and precursor composition. AMTS QDs obtained at 250 °C were spherical or polygonal with an average size of 5.4 nm or less. Decreasing the Ag fraction in precursors produced Ag-deficient, Mn-rich QDs, exhibiting high tolerance to nonstoichiometry. Their absorption spectra were blue-shifted, and the energy gap increased from 1.95 to 2.36 eV with a decrease in the Ag+/metal cation ratio in the precursors from 0.50 to 0.05. Although no photoluminescence (PL) was observed at room temperature, a broad PL peak appeared at 77 K around 740–760 nm. ZnS coating on AMTS QDs enhanced the PL, giving a broad emission at 690 nm. The magnetic properties originated from unpaired 3d electrons of Mn2+. For bioimaging applications, ZnS-coated AMTS (AMTS@ZnS) QDs were further modified with 3-mercaptopropionic acid, enabling stable dispersion in water without compromising the optical and magnetic properties. The hydrophilic AMTS@ZnS QDs exhibited high longitudinal relaxivity (r1), 19 mmol (Mn2+)−1 dm3 s–1, surpassing commercial Mn-based complexes (r1 < 10 mmol–1 dm3 s–1). Although the T1-weighted MRI intensity was similar at a fixed Mn2+ concentration, the QDs prepared with Ag/metal = 0.17 showed 1.7-fold higher relaxivity per QD than those with 0.44. In vivo MRI confirmed a clear signal enhancement at injection sites. The QDs internalized by cells were detectable by MRI in living animals. Given their negligible cytotoxicity compared to Cd-based QDs, AMTS QDs represent a promising next-generation MRI contrast agent, with additional potential for dual-mode bioimaging upon further PL optimization. |
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言語 |
en |
| 出版者 |
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出版者 |
ACS Publications |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1021/acsanm.5c03620 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2574-0970 |
| 書誌情報 |
en : ACS Applied Nano Materials
巻 8,
号 41,
p. 19952-19967,
発行日 2025-10-17
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| ファイル公開日 |
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|
日付 |
2026-10-17 |
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日付タイプ |
Available |
6723250_File000001_129828974.pdf (2.4 MB)
