| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2026-01-05 |
| タイトル |
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タイトル |
Stereoselective Synthesis of Delgocitinib and Its Diastereomer Using Organocatalyzed Michael Addition |
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言語 |
en |
| 著者 |
Morita, Kaito
Umekubo, Nariyoshi
Matsuzaki, Haruo
Tsutsumi, Ken
Yokoshima, Satoshi
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| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ORGANIC LETTERS], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-KBMJ2BHXWCT5F4EFQA9T].” |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Herein, we describe the stereoselective synthesis of delgocitinib and its diastereomer. Delgocitinib, a Janus kinase (JAK) inhibitor, is characterized by a diaza-spirocyclic structure consisting of pyrrolidine and azetidine rings. The organocatalyzed Michael addition of propanal with fumarate or maleimide facilitated the formation of contiguous tertiary stereogenic centers, leading to the stereoselective production of each diastereomer. Intramolecular C–H amination reactions introduced a nitrogen atom on one of the tertiary carbons, and subsequent azetidine formation constructed the spirocyclic system. |
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言語 |
en |
| 出版者 |
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出版者 |
ACS Publications |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1021/acs.orglett.5c01960 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1523-7060 |
| 書誌情報 |
en : ORGANIC LETTERS
巻 27,
号 25,
p. 6789-6793,
発行日 2025-06-27
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| ファイル公開日 |
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|
日付 |
2026-06-27 |
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日付タイプ |
Available |
morita_OL.pdf (676 KB)
