| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2026-01-27 |
| タイトル |
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タイトル |
Reactivity of Aryl Trifluoromethyl Ketimines toward Organometallic Nucleophiles under Protic and Aprotic Conditions |
|
言語 |
en |
| 著者 |
Yamamoto, Yoshihiko
Uchida, Hirotaka
Tadano, Ryu
Hayashi, Yutaro
Yasui, Takeshi
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| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
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|
権利情報 |
“This document is the Accepted Manuscript version of a Published Article that appeared in final form in [The Journal of Organic Chemistry], copyright © [American Chemical Society]. To access the final published article, see [https://pubs.acs.org/articlesonrequest/AOR-Q6DMECSNUDUXQWZDTDM3].” |
|
言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
The reactivity of aryl trifluoromethyl ketimines toward organometallic reagents was investigated and found that the reactivity of phenyl trifluoromethyl ketimine toward nBuLi is significantly higher than that of phenylglyoxylate imines under both on-water and conventional conditions. A variety of organolithium reagents underwent smooth 1,2-addition to aryl trifluoromethyl ketimines in THF at −78–0 °C, whereas Grignard reagents exhibited limited reactivity. These findings provide valuable insights for the development of efficient synthetic routes to trifluoromethylated amines, which are important motifs in medicinal chemistry. |
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言語 |
en |
| 出版者 |
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出版者 |
ACS Publications |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1021/acs.joc.5c02112 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0022-3263 |
| 書誌情報 |
en : The Journal of Organic Chemistry
巻 90,
号 46,
p. 16517-16531,
発行日 2025-11-21
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| ファイル公開日 |
|
|
日付 |
2026-11-21 |
|
日付タイプ |
Available |
JOC MS Rev.pdf (17.1 MB)
